Domenech, AdolfoMuñoz-Montiel, AnaGarcia-Casares, NataliaRioja, JoseRuiz-Esteban, PedroGutierrez-Castaño, PatriciaPrunera-Pardell, María JesusOlveira, CasildaValdivielso, PedroSanchez-Chaparro, Miguel Angel2023-01-252023-01-252018-07-17Domenech A, Muñoz-Montiel A, García-Casares N, Rioja J, Ruiz-Esteban P, Gutierrez-Castaño P, et al. High risk of subclinical atherosclerosis in COPD exacerbator phenotype. Respir Med. 2018 Aug;141:165-171http://hdl.handle.net/10668/12766It is not known whether COPD exacerbations contribute to an increased vascular risk already associated with the disease. For this reason, we prospectively evaluated 127 patients referred for a monographic COPD consultation. We classify as exacerbators those who had experienced two or more moderate exacerbations in the previous year, or who had had a hospital admission. All underwent a blood analysis, respiratory function tests, global cardiovascular and coronary risk estimates (with four of the most frequently used scores, and the Chronic Obstructive Pulmonary Disease Coronaropathy Risk (COPDCoRi) score, respectively); and an EcoDoppler to measure carotid intima-media thickness and the ankle-brachial index. Finally, we included 50 patients with exacerbator phenotypes and 57 with non-exacerbator phenotypes, ranging from 63 ± 7 years old, 74% of whom were male. The exacerbator phenotype increased the risk of carotid intima-media thickness above the 75th percentile range by a factor of almost three, independently of the severity of COPD and global cardiovascular risk. The association between the exacerbator phenotype and high c-IMT was more evident in patients under 65. In conclusion, the presence of subclinical atherosclerosis is independently associated with the exacerbator phenotype, with more pronounced differences in younger patient; which suggests that we should intensify control of vascular risk factors in these groups of patients.enAtherosclerosisCOPDCOPD exacerbationCardiovascular riskPhenotypeAgedAnkle Brachial IndexAtherosclerosisCarotid Intima-Media ThicknessComorbidityCoronary Artery DiseaseCross-Sectional StudiesDisease ProgressionFemaleHumansMaleMiddle AgedPhenotypePulmonary Disease, Chronic ObstructiveRisk Factorsresearch article30053963Restricted AccessFenotipoEnfermedad pulmonar obstructiva crónicaGrosor intima-media carotídeoAterosclerosisPruebas de función respiratoria10.1016/j.rmed.2018.07.0041532-3064http://www.resmedjournal.com/article/S0954611118302348/pdf