Beaumont, JavierArias, TeresaLópez, BegoñaZalba, GuillermoBelloqui, OscarGarcía-Bolao, IgnacioBarba, JoaquínTeresa, Eduardo deDíez, Javier2013-06-062013-06-062009Beaumont, Javier; Arias, Teresa; Lopez, Begona; Zalba, Guillermo; Beloqui, Oscar; Garcia-Bolao, Ignacio; et al. The L162V polymorphism of the PPARA gene is associated with stage C of heart failure. Circulation. 2009;120(18 Suppl 2):S5710009-7322http://hdl.handle.net/10668/1107Abstract 1921. Contents: Volume 120, Issue 18 Supplement; November 3, 2009 / Abstracts From Scientific Sessions 2009In human heart failure (HF) peroxisome proliferator-activated receptor alpha (PPAR alpha) is downregulated and consequently, the expression of genes involved in fatty acid oxidation repressed. The L162V (rs1800206) is a functional polymorphism of the human PPAR alpha gene (PPARA). In the present study we have investigated whether this polymorphism is associated with the development of stage C of HF.enAcil-CoA DeshidrogenasaCartilla de ADNInsuficiencia CardíacaPPAR alfaHumanosPlásmidosPolimorfismo GenéticoARN MensajeroMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-CH Group Donors::Acyl-CoA DehydrogenasesMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides::Polynucleotides::Oligonucleotides::Oligodeoxyribonucleotides::DNA PrimersMedical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Heart FailureMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptors::PPAR alphaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::PlasmidsMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, GeneticMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, MessengerMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedconference presentationopen access1524-4539