de-Las-Vecillas, LeticiaEguiluz-Gracia, IbonGiovannini, Mattia2023-02-092023-02-092021-04-08de Las Vecillas L, Eguiluz-Gracia I, Giovannini M. You might owe your mother more than you think. Allergy. 2021 Oct;76(10):3236-3237http://hdl.handle.net/10668/17560Immunoglobulin E (IgE)–mediated activation of mast cells (MC) has been historically linked to allergic reactions. Nevertheless, antibody-dependent MC degranulation can also be triggered by venoms from insects or reptiles. Of note, MC mediators provide efficient protection against the toxic compounds of venoms. Interestingly, antigen-specific (s) IgE-dependent MC activation could occur in newborns who are not able yet to mount functional antibody responses. In a recent article, Msallam et al. investigated the interactions among fetal MC, maternal sIgE, and fetal immune responses in mice and humans. Mouse fetal MC acquire a semi-mature phenotype according to their FcεRI and heparin expression levels, and increase in number during early development stages.enIgEMast cellsProtectionToxin hypothesisTransplacental transferFemaleHumansMothersImmunoglobulin EHypersensitivityAllergensresearch article33840097Restricted AccessInmunoglobulina ERecién nacidoInsectosInmunidadHeparinaHipersensibilidad10.1111/all.148551398-9995https://doi.org/10.22541/au.161401667.74000077/v1