Coll, ElisabethFernández-Ruiz, MarioPadilla, MaríaMoreso, FrancescHernández-Vicente, AnaYañez, IñigoMolina, MaríaVázquez-Sánchez, TeresaCrespo, MartaFacundo, CarmeRodríguez-Ferrero, María LuisaRuiz Fuentes, María CarmenLoinaz, CarmeloBernal, GabrielMelilli, EdoardoBravo, CarlosDiekmann, FritzLladó, LauraGarcía-Álvarez, Teresa MSalcedo, MagdalenaBeneyto, IsabelCastells, LluisAlonso, RodrigoRodríguez-Benot, AlbertoDíaz-Corte, CarmenGraus, JavierOrtiz-Bautista, CarlosGarcía-Cosío, María DoloresHinojal, RosaPeña, LucíaDomínguez-Gil, BeatrizSpanish Group for the Study of COVID-19 in Transplant Recipients.2025-01-072025-01-072021https://hdl.handle.net/10668/25275Few studies have analyzed differences in clinical presentation and outcomes in solid organ transplant (SOT) recipients with coronavirus disease 2019 (COVID-19) across different pandemic waves. In this multicenter, nationwide, prospective study, we compared demographics and clinical features, therapeutic management, and outcomes in SOT recipients diagnosed with COVID-19 in Spain before (first wave) or after (second wave) 13 July 2020. Of 1634 SOT recipients, 690 (42.2%) and 944 (57.8%) were diagnosed during the first and second periods, respectively. Compared with the first wave, recipients in the second were younger (median: 63 y [interquartile range, IQR: 53-71] versus 59 y [IQR: 49-68]; P We observed meaningful changes in demographics, therapeutic approaches, level of care, and outcomes between the first and second pandemic waves. However, outcomes have not improved in the more severe cases of posttransplant COVID-19.enAgedCOVID-19FemaleHumansImmunosuppression TherapyIntensive Care UnitsMaleMiddle AgedOrgan TransplantationProspective StudiesSARS-CoV-2research article34241988open access10.1097/TP.00000000000038731534-6080PMC8487705https://journals.lww.com/transplantjournal/fulltext/2021/10000/covid_19_in_solid_organ_transplant_recipients_in.10.aspxhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8487705/pdf