Hernández, DomingoVázquez, TeresaAlonso-Titos, JuanaLeón, MyriamCaballero, AbelardoCobo, María AngelesSola, EugeniaLópez, VerónicaRuiz-Esteban, PedroCruzado, Josep MaríaSellarés, JoanaMoreso, FrancescManonelles, AnnaTorio, AlbertoCabello, MercedesDelgado-Burgos, JuanCasas, CristinaGutiérrez, ElenaJironda, CristinaKanter, JuliaSerón, DanielTorres, Armando2022-11-212022-11-212021-04-29Hernández D, Vázquez T, Alonso-Titos J, León M, Caballero A, Cobo MA, et al. Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients. J Clin Med. 2021 Apr 29;10(9):1934.http://hdl.handle.net/10668/4370The impact of human leukocyte antigen (HLA)-mismatching on the early appearance of subclinical inflammation (SCI) in low-immunological-risk kidney transplant (KT) recipients is undetermined. We aimed to assess whether HLA-mismatching (A-B-C-DR-DQ) is a risk factor for early SCI. As part of a clinical trial (Clinicaltrials.gov, number NCT02284464), a total of 105 low-immunological-risk KT patients underwent a protocol biopsy on the third month post-KT. As a result, 54 presented SCI, showing a greater number of total HLA-mismatches (p = 0.008) and worse allograft function compared with the no inflammation group (48.5 ± 13.6 vs. 60 ± 23.4 mL/min; p = 0.003). Multiple logistic regression showed that the only risk factor associated with SCI was the total HLA-mismatch score (OR 1.32, 95%CI 1.06-1.64, p = 0.013) or class II HLA mismatching (OR 1.51; 95%CI 1.04-2.19, p = 0.032) after adjusting for confounder variables (recipient age, delayed graft function, transfusion prior KT, and tacrolimus levels). The ROC curve illustrated that the HLA mismatching of six antigens was the optimal value in terms of sensitivity and specificity for predicting the SCI. Finally, a significantly higher proportion of SCI was seen in patients with >6 vs. ≤6 HLA-mismatches (62.3 vs. 37.7%; p = 0.008). HLA compatibility is an independent risk factor associated with early SCI. Thus, transplant physicians should perhaps be more aware of HLA mismatching to reduce these early harmful lesions.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Kidney transplantationHLA compatibilitySubclinical inflammationBanff criteriaLow-immunological riskTacrolimusDelayed graft functionROC curveBiopsyMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Renal Replacement Therapy::Kidney TransplantationMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::TacrolimusMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Delayed Graft FunctionMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic ModelsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::ROC CurveMedical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA AntigensMedical Subject Headings::Anatomy::Body Regions::Transplants::AllograftsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk FactorsMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::InflammationMedical Subject Headings::Persons::Persons::Occupational Groups::Health Personnel::PhysiciansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsyresearch article33947168open accessTrasplante de riñónFuncionamiento retardado del injertoCurva ROCBiopsiaAntígenos HLAInflamación10.3390/jcm100919342077-0383PMC8125522