Díez-Manglano, JesúsSolís-Marquínez, Marta NatayaÁlvarez García, AndreaAlcalá-Rivera, NicolásMaderuelo Riesco, IreneGericó Aseguinolaza, MartínBeato Pérez, José LuisMéndez Bailón, ManuelLabirua-Iturburu Ruiz, Ane-ElbireGarcía Gómez, MiriamMartínez Cilleros, CarmenPesqueira Fontan, Paula MaríaAbella Vázquez, LucyBlázquez Encinar, Julio CésarBoixeda, RamonGil Sánchez, Ricardode la Peña Fernández, AndrésLoureiro Amigo, JoséEscobar Sevilla, JoaquínGuzmán Garcia, MarcosMartín Escalante, María DoloresMagallanes Gamboa, Jeffrey OskarMartínez González, Ángel LuisLumbreras Bermejo, CarlosAntón Santos, Juan MiguelSEMI-COVID-19 Network2025-01-072025-01-072021-02-19https://hdl.handle.net/10668/26407To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultAgedCOVID-19FemaleHealth PersonnelHospitalizationHumansMaleMiddle AgedOccupational ExposurePrevalenceRegistriesRetrospective StudiesRisk FactorsSARS-CoV-2Spainresearch article33606820open access10.1371/journal.pone.02474221932-6203PMC7894924https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247422&type=printablehttps://pmc.ncbi.nlm.nih.gov/articles/PMC7894924/pdf