Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC).

Casado-Diaz, AntonioTunez-Fiñana, IsaacMata-Granados, Jose MariaRuiz-Mendez, Maria VictoriaDorado, GabrielRomero-Sanchez, Maria ConcepcionNavarro-Valverde, CristinaQuesada-Gomez, Jose Manuel2023-01-252023-01-252017-01-26Casado-Díaz A, Túnez-Fiñana I, Mata-Granados JM, Ruiz-Méndez MV, Dorado G, Romero-Sánchez MC, et al. Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC). Exp Gerontol. 2017 Apr;90:71-78http://hdl.handle.net/10668/10848Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Interestingly, a novel olive-pomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants. Thus, diet of postmenopausal women was supplemented for two months with one of such by-products (distillate 6; D6), being rich in squalene. After treatment, serum from such women showed reduced both lipidic peroxidation and oxidized low-density lipoprotein (LDL). Besides, vitamin E and coenzyme Q10 levels increased. Furthermore, culture medium containing 10% of such serum both increased osteoblastogenesis and reduced adipogenesis in human MSC from bone marrow. Therefore, highly antioxidant by-products like D6 may represent a relevant source for development of functional products, for both prevention and treatment of degenerative pathologies associated with aging, like osteoporosis.enAdipocytesAgingMesenchymal stem-cellsOlive-pomace oil distillateOsteoblastsOsteoporosisAGS - Sur de SevillaAdipogenesisAgedAgingCells, culturedDietary supplementsFemaleHumansLipoproteins, LDLMesenchymal stem cellsMiddle agedOlive oilOsteoblastsOsteogenesisOsteoporosisPostmenopauseSerum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC).Research article28167238Aceite de olivaAdipogénesisCélulas cultivadasCélulas madre mesenquimatosasEnvejecimientoOsteoblastosOsteogénesisOsteoporosis10.1016/j.exger.2017.01.0241873-6815