Petta, SalvatoreSebastiani, GiadaViganò, MauroAmpuero, JavierWai-Sun Wong, VincentBoursier, JeromeBerzigotti, AnnalisaBugianesi, ElisabettaFracanzani, Anna LudovicaCammà, CalogeroEnea, MarcoGrottes, Marraud desDi Marco, VitoYounes, RamyKeyrouz, AlineMazzola, SergioMendoza, YulyPennisi, GraziaRomero-Gomez, ManuelCraxì, Antoniode Ledinghen, Victor2023-02-092023-02-092020-07-02http://hdl.handle.net/10668/15875Patients with advanced fibrosis related to nonalcoholic fatty liver disease (NAFLD) are at risk of developing hepatic and extrahepatic complications. We investigated whether, in a large cohort of patients with NAFLD and compensated advanced chronic liver disease, baseline liver stiffness measurements (LSMs) and their changes can be used to identify patients at risk for liver-related and extrahepatic events. We performed a retrospective analysis of consecutive patients with NAFLD (n = 1039) with a histologic diagnosis of F3-F4 fibrosis and/or LSMs>10 kPa, followed for at least 6 months, from medical centers in 6 countries. LSMs were made by FibroScan using the M or XL probe and recorded at baseline and within 1 year from the last follow-up examination. Differences between follow up and baseline LSMs were categorized as: improvement (reduction of more than 20%), stable (reduction of 20% to an increase of 20%), impairment (an increase of 20% or more). We recorded hepatic events (such as liver decompensation, ascites, encephalopathy, variceal bleeding, jaundice, or hepatocellular carcinoma [HCC]) and overall and liver-related mortality during a median follow-up time of 35 months (interquartile range, 19-63 months). Based on Cox regression analysis, baseline LSM was independently associated with occurrence of hepatic decompensation (hazard ratio [HR], 1.03; 95% CI, 1.02-1.04; P In patients with NAFLD and compensated advanced chronic liver disease, baseline LSM and change in LSM are associated with risk of liver-related events and mortality.enNASHPrognostic FactorSteatohepatitiscACLDCarcinoma, HepatocellularElasticity Imaging TechniquesEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansLiverLiver CirrhosisLiver NeoplasmsNon-alcoholic Fatty Liver DiseaseRetrospective Studiesresearch article32621970open access10.1016/j.cgh.2020.06.0451542-7714http://www.cghjournal.org/article/S1542356520309083/pdf