Barrios, R Haridian SosaBurguera Vion, VíctorÁlvarez Nadal, MartaCintra Cabrera, MelissaElías Triviño, SandraVilla Hurtado, DanielOrtego, SofíaFernández Lucas, MilagrosRivera-Gorrin, Maite2025-01-072025-01-072021https://hdl.handle.net/10668/27589Percutaneous renal biopsy (PRB) is invasive, and bleeding-related complications are a concern. Desmopressin (DDAVP) is a selective type 2 vasopressin receptor-agonist also used for haemostasis. To evaluate the side effects of intravenous (IV) weight-adjusted desmopressin preceding PRB. This was a retrospective study of renal biopsies performed by nephrologists from 2013 to 2017 in patients who received single-dose DDAVP pre-PRB. Of 482 PRBs, 65 (13.5%) received DDAVP (0.3 µg/kg); 55.4% of the PRBs were native kidneys. Desmopressin indications were altered platelet function analyser (PFA)-100 results (75.3% of the patients), urea >24.9 mmol/L (15.5%), antiplatelet drugs (6.1%) and thrombocytopaenia (3%). Of the 65 patients, 30.7% had minor asymptomatic complications, and 3 patients had major complications. Pre-PRB haemoglobin (Hb) 24.9 mmol/L (15.5%), antiplatelet drugs (6.1%) and thrombocytopaenia (3%). Of the 65 patients, 30.7% had minor asymptomatic complications, and 3 patients had major complications. Pre-PRB haemoglobin (Hb) 10 g/L, and altered collagen-epinephrine (Col-Epi) time was a significant risk factor for overall complications. Mean sodium decrease was 0.6 ± 3 mmol/L. Hyponatraemia without neurological symptoms was diagnosed in two patients; no cardiovascular events occurred. Hyponatraemia after single-dose DDAVP is rare. A single IV dose of desmopressin adjusted to the patient's weight is safe as pre-PRB bleeding prophylaxis.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/1-deamino8-D-arginine vasopressinRenal biopsybleedingcardiovascular eventdesmopressin safetyhyponatraemiainterventional nephrologyprophylaxissecondary effecturaemiaBiopsyDeamino Arginine VasopressinHemorrhageHemostaticsHumansRetrospective Studiesresearch article34590925open access10.1177/030006052110407641473-2300PMC8489756https://journals.sagepub.com/doi/pdf/10.1177/03000605211040764https://pmc.ncbi.nlm.nih.gov/articles/PMC8489756/pdf