Braidy, NadySmani, TarikNaziroglu, Mustafa2023-02-092023-02-092021-03-11Braidy N, Smani T, Naziroglu M. Editorial: Involvements of TRP Channels, Oxidative Stress and Apoptosis in Neurodegenerative Diseases. Front Physiol. 2021 Mar 11;12:649230.1664-042Xhttp://hdl.handle.net/10668/17417The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids , lipids , and protein , resulting in structural degeneration, apoptosis , functional decline, and age-related degenerative diseases involving the cardiovascular, endocrine, neurologic, immune, respiratory, gastrointestinal, and reproductive systems . The transient receptor potential (TRP) protein superfamily is composed of several cation -permeable channels that are widely distributed in mammalian cells . TRP channels can be divided into six subfamilies that are dependent on their sequence identity. These channels play a crucial role in the regulation of oxidative stress and should be considered as likely targets for the treatment of age-related neurodegenerative diseases associated with chronic oxidative stress , decreases in metabolic regulation , and cell viability .enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/TRPagingapoptosisneurodegenerationoxidative stressAnimalsCell SurvivalNeurodegenerative DiseasesOxidative StressFree RadicalsGenitaliaLipidsEditorial33776800open accessEstrés oxidativoProteínasEnfermedadCélulasApoptosisMigrantesCationesGenitalesLípidos10.3389/fphys.2021.649230PMC7992006https://www.frontiersin.org/articles/10.3389/fphys.2021.649230/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992006/pdf