Leuermann, JonasFernández-Gavela, AdriánTorres-Cubillo, AntoniaPostigo, SergioSánchez-Postigo, AlejandroLechuga, Laura M.Halir, RobertMolina-Fernández, Íñigo2021-05-282021-05-282019-08-23Leuermann J, Fernández-Gavela A, Torres-Cubillo A, Postigo S, Sánchez-Postigo A, Lechuga LM, et al. Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices. Sensors. 2019;19(17):3671.http://hdl.handle.net/10668/3341Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e., the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of ∼ 10−8RIU with a silicon nitride sensor operating at telecom wavelengths.enBiosensorsCoherent detectionInterferometerLimit of detectionSilicon photonicsTécnicas biosensiblesLímite de detecciónMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Molecular Probe Techniques::Biosensing TechniquesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::InterferometryMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::Limit of DetectionMedical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Engineering::Optics and PhotonicsMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Silicon Compoundsresearch article31450817Acceso abierto10.3390/s191736711424-8220PMC6749351