de Melo, Gessika Araujode Oliveira, Eliane AraujoDos Santos Andrade, Suellen Mary MarinhoFernandez-Calvo, BernardinoTorro, Nelson2023-02-092023-02-092020-10-21de Melo GA, de Oliveira EA, Dos Santos Andrade SMM, Fernández-Calvo B, Torro N. Comparison of two tDCS protocols on pain and EEG alpha-2 oscillations in women with fibromyalgia. Sci Rep. 2020 Nov 3;10(1):18955http://hdl.handle.net/10668/16539Transcranial Direct Current Stimulation (tDCS) has been used as an alternative treatment for pain reduction in fibromyalgia. In this study, in addition to behavioral measures, we analyzed oscillations in alpha 2 frequency band in the frontal, occipital, and parietal regions, in response to the application of two neuromodulation protocols in fibromyalgia. The study was a randomized, double-blind, placebo-controlled clinical trial with 31 women diagnosed with fibromyalgia. The participants were allocated to three groups with the anodic stimulation applied on the left motor cortex: Group 1, for five consecutive days; Group 2, for 10 consecutive days; and Group 3, sham stimulation for five consecutive days. Statistical analysis showed a reduction in pain intensity after treatment for groups in general [F (1.28) = 8.02; p = 0.008; η2 = 0.223], in addition to a reduction in alpha 2 in the frontal (p = 0.039; d = 0.384) and parietal (p = 0.021; d = 0.520) regions after the treatment on five consecutive days. We conclude that neuromodulation protocols produced similar effects on pain reduction, but differed with respect to the changes in the alpha 2 frequency band in the frontal and parietal regions.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultDeep brain stimulationDouble-blind methodElectric stimulationElectric stimulation therapyElectroencephalographyElectrophysiologyFemaleFibromyalgiaHumansMiddle agedNeurosciencesPainPain managementResearch article33144646open accessElectroencefalografíaElectrofisiologíaEstimulación eléctricaEstimulación encefálica profundaFibromialgiaManejo del dolor10.1038/s41598-020-75861-52045-2322PMC7609530https://www.nature.com/articles/s41598-020-75861-5.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609530/pdf