Donat-Vargas, CarolinaGuerrero-Zotano, ÁngelCasas, AnaBaena-Cañada, José ManuelLope, VirginiaAntolín, SilviaGarcia-Saénz, José ÁngelBermejo, BegoñaMuñoz, MontserratRamos, Manuelde Juan, AnaJara Sánchez, CarlosSánchez-Rovira, PedroAntón, AntonioBrunet, JoanGavilá, JoaquínSalvador, JavierArriola Arellano, EsperanzaBezares, SusanaFernández de Larrea-Baz, NereaPérez-Gómez, BeatrizMartín, MiguelPollán, Marina2025-01-072025-01-072021-09-06https://hdl.handle.net/10668/25305Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption ( The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdolescentAdultAlcohol DrinkingBreast NeoplasmsCase-Control StudiesFemaleHumansMiddle AgedPostmenopausePremenopauseRisk FactorsSpainSurveys and QuestionnairesYoung Adultresearch article34483338open access10.1038/s41416-021-01492-w1532-1827PMC8505448https://www.nature.com/articles/s41416-021-01492-w.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8505448/pdf