Holubiec, Mariana IRomero, Juan IBlanco, EduardoTornatore, Tamara LogicaSuarez, JuanRodriguez-de-Fonseca, FernandoGaleano, PabloCapani, Francisco2023-01-252023-01-252017-06-01Holubiec MI, Romero JI, Blanco E, Tornatore TL, Suarez J, Rodríguez de Fonseca F, et al. Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia. Neurosci Lett. 2017 Jul 13;653:269-275http://hdl.handle.net/10668/11271Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGLα, NAPE-PLD and FAAH) and their receptors (CB1 and PPARα). We found a decrease in NAPE-PLD and PPARα expression. Since NAPE-PLD and PPARα take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. These data agree with previous results obtained in the hippocampus and encourage us to develop further studies using AEs as potential neuroprotective compounds.enCB1DAGLαDorsal striatumNAPE-PLDPPARαPerinatal asphyxiaAnimalsAnimals, NewbornAsphyxia NeonatorumCorpus StriatumDisease Models, AnimalEndocannabinoidsLipoprotein LipasePPAR alphaPhospholipase DRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Signal Transductionresearch article28579484Restricted AccessReceptores activados del proliferador del peroxisomaEnzimasAsfixiaHipocampoControl social formalEnfermedades del sistema nervioso10.1016/j.neulet.2017.05.0681872-7972https://ri.conicet.gov.ar/bitstream/11336/38529/5/CONICET_Digital_Nro.9fe6dfed-20fc-4ed3-8d52-a23cd466caea_D.pdf