Oluwabusola, Emmanuel TTabudravu, Jioji NAl Maqbali, Khalid SAnnang, FrederickPérez-Moreno, GuiomarReyes, FernandoJaspars, Marcel2023-02-092023-02-092020-09-29http://hdl.handle.net/10668/15974Ten bromotyrosine alkaloids were isolated and characterised from the marine sponge Aplysinella rhax (de Laubenfels 1954) collected from the Fiji Islands, which included one new bromotyrosine analogue, psammaplin P and two other analogues, psammaplin O and 3-bromo-2-hydroxy-5-(methoxycarbonyl)benzoic acid, which have not been previously reported from natural sources. HR-ESI-MS, 1D and 2D NMR spectroscopic methods were used in the elucidation of the compounds. Bisaprasin, a biphenylic dimer of psammaplin A, showed moderate activity with IC50 at 19±5 and 29±6 μM against Trypanzoma cruzi Tulahuen C4, and the lethal human malaria species Plasmodium falciparum clone 3D7, respectively, while psammaplins A and D exhibited low activity against both parasites. This is the first report of the antimalarial and antitrypanosomal activity of the psammaplin-type compounds. Additionally, the biosynthesis hypotheses of three natural products were proposed.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Chagas diseasebromotyrosinemalariapsammaplinspongeAlkaloidsAnimalsAntiprotozoal AgentsBiological ProductsMolecular StructureParasitic Sensitivity TestsPlasmodium falciparumPoriferaTrypanosoma cruziTyrosineresearch article32697400open access10.1002/cbdv.2020003351612-1880https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbdv.202000335