van der Meer, Thomas PArtacho-Cordón, FranciscoSwaab, Dick FStruik, DickyMakris, Konstantinos CWolffenbuttel, Bruce H RFrederiksen, Hannevan Vliet-Ostaptchouk, Jana V2023-01-252023-01-252017-09-13http://hdl.handle.net/10668/11577Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI 30 and BMIenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/bisphenol-AbrainhypothalamusmethylparabenobesityparabensphenolsAdultBrainChromatography, LiquidEndocrine DisruptorsEnvironmental ExposureEnvironmental PollutantsFemaleHumansMaleObesityPilot ProjectsTandem Mass Spectrometryresearch article28902174open access10.3390/ijerph140910591660-4601PMC5615596https://www.mdpi.com/1660-4601/14/9/1059/pdf?version=1505381259https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615596/pdf