Márquez Contreras, EmilioVázquez-Rico, IgnacioBaldonedo-Suárez, AguedaMárquez-Rivero, SaraJiménez, JesúsMachancoses, FranciscoMorano-Báez, RocíoLeon-Justel, Antonio2023-01-252023-01-252018-10-252048-7177http://hdl.handle.net/10668/13277To evaluate the impact that the moderate and regular consumption of Cinco Jotas acorn-fed 100% Iberian ham has on overall cardiovascular risk, lipid parameters, blood pressure, and weight. A longitudinal, analytical, and quasi-experimental clinical study with repeated measures was carried out with 100 randomly selected individuals in primary care. The sample population included men and women (64%) between the ages of 25 and 55 (42.08, SD 9.6) who were not diagnosed with any cardiovascular illness or diabetes, were not undergoing antihypertensive treatment, nor taking lipid-lowering drugs. There were four visits during a 2-week washout period for the first of three phases. Phases 2 and 3 included an 8-week habitual diet phase followed by an 8-week intervention phase when participants consumed 40 g daily of acorn-fed 100% Cinco Jotas Iberian ham. Measurements of cardiovascular risk factors were taken following the SCORE table. These included total cholesterol, high-density lipoproteins cholesterol (HDL-c), low-density lipoproteins cholesterol (LDL-c), triglycerides (TG), and weight. The average vascular risk (SCORE) was 0.20 (SD 0.49) before the consumption phase and 0.18 (SD 0.48) at the end of the study (p > 0.05). An increase in HDL-c of 5 mg/dl was observed while there was a decrease in LDL-c and TG of 10 mg/dl (p  0.05). An increase in HDL-c of 5 mg/dl was observed while there was a decrease in LDL-c and TG of 10 mg/dl (p  0.05). The daily consumption of 40 g of Cinco Jotas acorn-fed 100% Iberian ham does not increase the risk of cardiovascular disease and has a favorable impact on lipid levels without affecting blood pressure or weight.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/cardiovascular diseasecholesterolhamnutritionresearch article30510757open access10.1002/fsn3.869PMC6261208https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.869https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261208/pdf