Sánchez, ElenaGarcía de la Torre, IgnacioSacnún, MónicaGoñi, MarioBerbotto, GuillermoPaira, SergioMusuruana, Jorge LuisGraf, CésarAlvarellos, AlejandroMessina, Osvaldo DBabini, AlejandraStrusberg, IngridMarcos, Juan CarlosScherbarth, HugoSpindler, AlbertoQuinteros, AnaToloza, SergioMoreno, José Luis CCatoggio, Luis JTate, GuillermoEimon, AliciaCitera, GustavoPellet, Antonio CatalánNasswetter, GustavoCardiel, Mario HMiranda, PedroBallesteros, FranciscoEsquivel-Valerio, Jorge AMaradiaga-Ceceña, Marco AAcevedo-Vásquez, Eduardo MGarcía, Conrado GarcíaTusié-Luna, TeresaPons-Estel, Bernardo AAlarcón-Riquelme, Marta EGENAR Study2023-01-252023-01-252017-11-010315-162Xhttp://hdl.handle.net/10668/11760To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America. Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history. Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles.enADMIXTUREAMERINDIANLATIN AMERICANRHEUMATOID ARTHRITISSMOKINGAdultAge FactorsAgedAllelesAnti-Inflammatory Agents, Non-SteroidalAntirheumatic AgentsArgentinaArthritis, RheumatoidChileFemaleGenotypeHumansIndians, North AmericanIndians, South AmericanIsoxazolesLeflunomideMaleMethotrexateMexicoMiddle AgedPeruRadiographyRheumatoid FactorSex FactorsSulfasalazineresearch article29093158open access10.3899/jrheum.160485https://www.jrheum.org/content/jrheum/44/12/1804.full.pdf