Torres-Peña, Jose D.Rangel-Zuñiga, Oriol A.Alcala-Diaz, Juan F.Lopez-Miranda, JoseDelgado-Lista, Javier2022-07-292022-07-292020-07-24Torres-Peña JD, Rangel-Zuñiga OA, Alcala-Diaz JF, Lopez-Miranda J, Delgado-Lista J. Mediterranean Diet and Endothelial Function: A Review of its Effects at Different Vascular Bed Levels. Nutrients. 2020 Jul 24;12(8):2212http://hdl.handle.net/10668/3854The Mediterranean diet has recently been the focus of considerable attention as a palatable model of a healthy diet. Its influence on many cardiovascular risk factors, combined with its proven effect in reducing the risk of cardiovascular events in primary prevention, has boosted scientific interest in this age-old nutritional model. Many of the underlying mechanisms behind its health-giving effects have been revealed, from the modulation of the microbiota to the function of high-density lipoproteins (HDL), and it seems to deliver its health benefits mainly by regulating several key mechanisms of atherosclerosis. In this review, we will review the evidence for its regulation of endothelial function, a key element in the early and late stages of atherosclerosis. In addition, we will assess studies which evaluate its effects on the functioning of different arterial territory vessels (mainly the microvascular, peripheral and central vascular beds), focusing mainly on the capillary, brachial and carotid arteries. Finally, we will evaluate the molecular mechanisms which may be involved.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Endothelial functionCardiovascular diseaseMediterranean dietCélulas endotelialesEnfermedades cardiovascularesDieta mediterráneaMedical Subject Headings::Persons::Persons::Age Groups::AdultMedical Subject Headings::Persons::Persons::Age Groups::Adult::AgedMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::ArteriosclerosisMedical Subject Headings::Anatomy::Cardiovascular System::Blood VesselsMedical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Arteries::Brachial ArteryMedical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Microvessels::CapillariesMedical Subject Headings::Diseases::Cardiovascular DiseasesMedical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Arteries::Carotid ArteriesMedical Subject Headings::Phenomena and Processes::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Digestive System Processes::EatingMedical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Endothelium, VascularMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::MicrovesselsMedical Subject Headings::Persons::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Tunica IntimaMedical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Cardiovascular Physiological Processes::Hemodynamics::VasodilationMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet, Mediterraneanreview article32722321open access10.3390/nu120822122072-6643PMC7469011