Ruiz-Leyva, LeandroVazquez-Agredos, AnaJimenez-Garcia, Ana MLopez-Guarnido, OlgaPla, AntonioPautassi, Ricardo MarcosMoron Henche, IgnacioCendan, Cruz Miguel2023-05-032023-05-032022-01-20Ruiz-Leyva L, Vázquez-Ágredos A, Jiménez-García AM, López-Guarnido O, Pla A, Pautassi RM, Morón Henche I, et al. From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self-administration in male rats. Addict Biol. 2022 Mar;27(2):e13153.http://hdl.handle.net/10668/19885Animal models of alcohol (ethanol) self-administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self-administration co-occurs with other addictive behaviours. The present study aims to validate a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Over 10 sessions, Wistar rats were exposed to binge or control eating (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively, derived from a highly palatable food), immediately followed by two-bottle choice intake tests (2%, 6%, 10% or 14% w/w ethanol vs. water). Rats exposed to binge eating drank significantly more 6% or 10% (w/w) ethanol than control peers, reaching up to 6.3 gEtOH /kg. Rats stimulated with 2%, 6%, 10% or 14% ethanol after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within-group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating. Blood ethanol levels significantly correlated with ethanol consumption; and the more ethanol consumed, the greater the distance travelled in an open field test conducted after the two-bottle choice test. Altogether, this self-administration model seems a valid and robust alternative with remarkable potential for research on different stages of the alcohol addiction and, particularly, to assess interactions between alcohol consumption and others addictive-like behaviours.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/binge drinkingbinge eatingethanolnaltrexoneself-administrationAlcohol DrinkingAnimalsBinge DrinkingBinge-Eating DisorderEthanolMaleRatsRats, WistarSelf Administrationresearch article35229947open accessConsumo excesivo de bebidasAlcohólicasConsumo de bebidas alcohólicasEtanolMasculinoRatas WistarRatas WistarTrastorno por atracón10.1111/adb.131531369-1600PMC9285499https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/adb.13153https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285499/pdf