Nestares, TeresaMartin-Masot, RafaelFlor-Alemany, MartaBonavita, AntonelaMaldonado, JoseAparicio, Virginia A2023-02-092023-02-092020-12-29Nestares T, Martín-Masot R, Flor-Alemany M, Bonavita A, Maldonado J, Aparicio VA. Influence of Ultra-Processed Foods Consumption on Redox Status and Inflammatory Signaling in Young Celiac Patients. Nutrients. 2021 Jan 6;13(1):156.http://hdl.handle.net/10668/16939The current study was designed to assess the influence of consumption of ultra-processed (UPF) on oxidative/antioxidant balance and evoked inflammatory signaling in young patients with celiac disease (CD). The study included 85 children. The celiac group (n = 53) included children with CD with a long (>18 months, n = 17) or recent (18 months, n = 17) or recent (<18 months, n = 36) adherence to a gluten-free diet (GFD). The control group (n = 32) included healthy children with a significantly lower consumption of UPF compared to the CD group, both expressed as kcal/day (p = 0.043) and as percentage of daily energy intake (p = 0.023). Among children with CD, the group with the lowest consumption of UPF (below the 50% of daily energy intake) had a greater Mediterranean diet (MD) adherence and higher moderate physical activity levels. In addition, CD children with the lowest consumption of UPF had healthier redox (lower soluble superoxide dismutase-1 and 15-F2t-isoprostanes) and inflammatory profiles (lower macrophage inflammatory protein-1α) compared to the group with the highest consumption of UPF (all, p < 0.05) regardless of the time on a GFD. These findings highlight the importance of a correct monitoring of the GFD. An unbalanced GFD with high consumption of UPF and an unhealthy pattern with less physical activity and worse adherence to MD results in a worse inflammatory profile, which could act as a parallel pathway that could have important consequences on the pathophysiology of the disease.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/celiac diseasechildrengluten-free dietinflammatory signalingoxidative stressultra-processed foodsAdolescentAntibodiesAntioxidantsBiomarkersCeliac DiseaseChildDiet, Gluten-FreeDiet, MediterraneanEnergy IntakeFemaleFoodHumansMaleOxidative StressSignal TransductionSpainSuperoxide Dismutase-1research article33418957open accessTransducción de SeñalSuperóxido Dismutasa-1Ingestión de energíaEstrés oxidativoEnfermedad celíacaDieta sin glutenDieta MediterráneaBiomarcadores10.3390/nu130101562072-6643PMC7825019https://www.mdpi.com/2072-6643/13/1/156/pdf?version=1610442699https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825019/pdf