Arenas-Montes, JavierPerez-Martinez, PabloVals-Delgado, CristinaRomero-Cabrera, Juan LuisCardelo, Magdalena P.Leon-Acuña, AnaQuintana-Navarro, Gracia M.Alcala-Diaz, Juan F.Lopez-Miranda, JoseCamargo, AntonioPerez-Jimenez, Francisco2022-12-052022-12-052021-08-09Arenas-Montes J, Perez-Martinez P, Vals-Delgado C, Romero-Cabrera JL, Cardelo MP, Leon-Acuña A, et al. Owning a Pet Is Associated with Changes in the Composition of Gut Microbiota and Could Influence the Risk of Metabolic Disorders in Humans. Animals. 2021 Aug 9;11(8):2347http://hdl.handle.net/10668/4455Pet ownership positively influences clinical outcomes in cardiovascular prevention. Additionally, cardiovascular disease (CVD) has been previously linked to microbiota dysbiosis. We evaluated the influence of owning a pet and its relationship with the intestinal microbiota. We analyzed the gut microbiota from 162 coronary patients from the CORDIOPREV study (NCT00924937) according to whether they owned pets (n = 83) or not (n = 79). The pet-owner group was further divided according to whether they owned dogs only (n = 28) or not (n = 55). A 7-item pet-owners test score was used. Patients who owned pets had less risk of metabolic syndrome (MetS) (OR = 0.462) and obesity (OR = 0.519) and were younger (p < 0.001) than patients who did not own pets. Additionally, patients who owned dogs had less risk of MetS (OR = 0.378) and obesity (OR = 0.418) and were younger (p < 0.001) than patients who did not own pets. A preponderance of the genera Serratia and Coprococcus was found in the group of owners, while the genera Ruminococcus, an unknown genus of Enterobacteriaceae and Anaerotruncus were preponderant in the group of non-owners. In patients who owned dogs, Methanobrevibacter and two more genera, Coprococcus and Oscillospira, were more common. Our study suggests that the prevalence of MetS and obesity in CVD patients is lower in pet owners, and that pet ownership could be a protective factor against MetS through the shaping of the gut microbiota. Thus, owning a pet could be considered as a protective factor against cardiometabolic diseases.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Gut microbiotaDysbiosisDogCardiometabolic diseasesMicrobioma gastrointestinalDisbiosisPerrosFactores de riesgo cardiometabólicoEnfermedades metabólicasMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Carnivora::Canidae::DogsMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Control, Formal::Jurisprudence::OwnershipMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Diseases::Cardiovascular DiseasesMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic DiseasesMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::ObesityMedical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Gram-Positive Cocci::RuminococcusMedical Subject Headings::Information Science::Information Science::Data Collection::Vital Statistics::Morbidity::PrevalenceMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesityresearch article34438804open access10.3390/ani110823472076-2615PMC8388619