Alcala-Santiago, AngelaRodriguez-Barranco, MiguelRava, MartaJimenez-Sousa, Maria AngelesGil, AngelSanchez-Perez, Maria-JoseMolina-Montes, Esther2023-05-032023-05-032022-11-14Alcalá-Santiago Á, Rodríguez-Barranco M, Rava M, Jiménez-Sousa MÁ, Gil Á, Sánchez MJ, et al. Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations. Int J Mol Sci. 2022 Nov 17;23(22):14256.http://hdl.handle.net/10668/21217Vitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate genetic/biological databases on the biological implications of a VD deficiency and its association with diseases, to further explore its link with COVID-19. The genetic variants of both a VD deficiency and COVID-19 were identified in the genome-wide association studies (GWAS) catalog and other sources. We conducted enrichment analyses (considering corrected p-valuesenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2computational biologygenesnutritionvitamin DHumansCOVID-19Genome-Wide Association StudyVitamin D DeficiencyVitamin DVitaminsresearch article36430729open accessDeficiencia de Vitamina DEstudio de asociación del genoma completoVitaminasVitamina DHumanos10.3390/ijms2322142561422-0067PMC9699081https://www.mdpi.com/1422-0067/23/22/14256/pdf?version=1668755078https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699081/pdf