Severe Covid-19 GWAS GroupEllinghaus, DavidDegenhardt, FraukeBujanda, LuisButi, MariaAlbillos, AgustínInvernizzi, PietroFernández, JavierPrati, DanieleBaselli, GuidoAsselta, RosannaGrimsrud, Marit MMilani, ChiaraAziz, FátimaKässens, JanMay, SandraWendorff, MareikeWienbrandt, LarsUellendahl-Werth, FlorianZheng, TenghaoYi, Xiaolide Pablo, RaúlChercoles, Adolfo GPalom, AdrianaGarcia-Fernandez, Alba-EstelaRodriguez-Frias, FranciscoZanella, AlbertoBandera, AlessandraProtti, AlessandroAghemo, AlessioLleo, AnaBiondi, AndreaCaballero-Garralda, AndreaGori, AndreaTanck, AnjaCarreras Nolla, AnnaLatiano, AnnaFracanzani, Anna LudovicaPeschuck, AnnaJulià, AntonioPesenti, AntonioVoza, AntonioJiménez, DavidMateos, BeatrizNafria Jimenez, BeatrizQuereda, CarmenPaccapelo, CinziaGassner, ChristophAngelini, ClaudioCea, CristinaSolier, AuroraPestaña, DavidMuñiz-Diaz, EduardoSandoval, ElenaParaboschi, Elvezia MNavas, EnriqueGarcía Sánchez, FélixCeriotti, FerruccioMartinelli-Boneschi, FilippoPeyvandi, FloraBlasi, FrancescoTéllez, LuisBlanco-Grau, AlbertHemmrich-Stanisak, GeorgGrasselli, GiacomoCostantino, GiorgioCardamone, GiuliaFoti, GiuseppeAneli, SerenaKurihara, HayatoElAbd, HeshamMy, IlariaGalván-Femenia, IvánMartín, JavierErdmann, JeanetteFerrusquía-Acosta, JoseGarcia-Etxebarria, KoldoIzquierdo-Sanchez, LauraBettini, Laura RSumoy, LauroTerranova, LeonardoMoreira, LeticiaSantoro, LuigiScudeller, LuigiaMesonero, FranciscoRoade, LuisaRühlemann, Malte CSchaefer, MarcoCarrabba, MariaRiveiro-Barciela, MarFiguera Basso, Maria EValsecchi, Maria GHernandez-Tejero, MaríaAcosta-Herrera, MarialbertD'Angiò, MariellaBaldini, MarinaCazzaniga, MarinaSchulzky, MartinCecconi, MaurizioWittig, MichaelCiccarelli, MicheleRodríguez-Gandía, MiguelBocciolone, MonicaMiozzo, MonicaMontano, NicolaBraun, NicoleSacchi, NicolettaMartínez, NildaÖzer, OnurPalmieri, OrazioFaverio, PaolaPreatoni, PaolettaBonfanti, PaoloOmodei, PaoloTentorio, PaoloCastro, PedroRodrigues, Pedro MBlandino Ortiz, Aaronde Cid, RafaelFerrer, RicardGualtierotti, RobertaNieto, RosaGoerg, SiegfriedBadalamenti, SalvatoreMarsal, SaraMatullo, GiuseppePelusi, SerenaJuzenas, SimonasAliberti, StefanoMonzani, ValterMoreno, VictorWesse, TanjaLenz, Tobias LPumarola, TomasRimoldi, ValeriaBosari, SilvanoAlbrecht, WolfgangPeter, WolfgangRomero-Gómez, ManuelD'Amato, MauroDuga, StefanoBanales, Jesus MHov, Johannes RFolseraas, TrineValenti, LucaFranke, AndreKarlsen, Tom H2023-02-092023-02-092020-06-17http://hdl.handle.net/10668/15770There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case-control panels. We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system. (Funded by Stein Erik Hagen and others.).enABO Blood-Group SystemAgedBetacoronavirusCOVID-19Case-Control StudiesChromosomes, Human, Pair 3Chromosomes, Human, Pair 9Coronavirus InfectionsFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansItalyMaleMiddle AgedMultigene FamilyPandemicsPneumonia, ViralPolymorphism, Single NucleotideRespiratory InsufficiencySARS-CoV-2Spainresearch article32558485open access10.1056/NEJMoa20202831533-4406PMC7315890https://doi.org/10.1056/nejmoa2020283https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315890/pdf