Caravaca Perez, PedroGonzalez-Juanatey, Jose RNuche, JorgeMatute-Blanco, LuciaSerrano, IsabelMartinez Selles, ManuelVazquez Garcia, RafaelMartinez Dolz, LuisGomez-Bueno, ManuelPascual Figal, DomingoCrespo-Leiro, Maria GGarcia-Osuna, AlvaroOrdoñez-Llanos, JordiCinca Cuscullola, JuanGuerra, Jose MDelgado, Juan F2023-05-032023-05-032022-04-07Caravaca Perez P, González-Juanatey JR, Nuche J, Matute-Blanco L, Serrano I, Martínez Selles M, et al. Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure. Front Cardiovasc Med. 2022 Apr 7;9:8616512297-055Xhttp://hdl.handle.net/10668/20548Galectin-3 (Gal-3) is an inflammatory marker associated with the development and progression of heart failure (HF). A close relationship between Gal-3 levels and renal function has been observed, but data on their interaction in patients with acute HF (AHF) are scarce. We aim to assess the prognostic relationship between renal function and Gal-3 during an AHF episode. This is an observational, prospective, multicenter registry of patients hospitalized for AHF. Patients were divided into two groups according to estimated glomerular filtration rate (eGFR): preserved renal function (eGFR ≥ 60 mL/min/1.73 m2) and renal dysfunction (eGFR We included 1,201 patients in whom Gal-3 values were assessed at admission. The median value of Gal-3 in our population was 23.2 ng/mL (17.3-32.1). Gal-3 showed a negative correlation with eGFR (rho = -0.51; p Gal-3 is a marker of high mortality in patients with acute HF and renal dysfunction. Renal function influences the prognostic value of Gal-3 levels, which should be adjusted by eGFR for a correct interpretation.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acute heart failure (AHF)Cardiorenal syndrome (CRS)Galectin-3 (Gal-3)PrognosisRenal functionGalectin 3PrognosisGlomerular filtration rateProspective studiesHeart failureKidneyKidney diseasesRegistriesResearch article35463785open accessEnfermedades renalesEstudios prospectivosGalectina 3Insuficiencia cardíacaPronósticoRiñónSistema de registrosTasa de filtración glomerular10.3389/fcvm.2022.861651PMC9021836https://www.frontiersin.org/articles/10.3389/fcvm.2022.861651/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021836/pdf