Martin-Rodriguez, Jose LuisGonzalez-Cantero, JorgeGonzalez-Cantero, AlvaroArrebola, Juan PedroGonzalez-Calvin, Jorge Luis2023-01-252023-01-252017http://hdl.handle.net/10668/11133Recognition of the close relationship of nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus 2, obesity, metabolic syndrome, and cardiovascular disease has stimulated growing interest in NAFLD as a public health problem. Serum alanine aminotransferase (ALT) has been proposed as a marker of NAFLD, but levels are within the range currently considered "normal" in a large proportion of NAFLD subjects.The aim of the study was to determine the diagnostic accuracy of serum ALT for identifying individuals with NAFLD, using 3-Tesla (T) magnetic resonance spectroscopy (H-MRS).A cross-sectional study was conducted in 129 healthy subjects. Liver triglyceride content was quantified by H-MRS. NAFLD was defined as liver triglyceride content greater than 5.56%.Liver triglyceride content was >5.56% in 79 participants (NAFLD) and lower in the remaining 50 (normal). Serum ALT levels correlated positively with liver triglyceride content (r = 0.58, P 5.56% in 79 participants (NAFLD) and lower in the remaining 50 (normal). Serum ALT levels correlated positively with liver triglyceride content (r = 0.58, P enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/AdultAgedAlanine TransaminaseAnthropometryArea Under CurveBiomarkersFemaleHumansInsulin ResistanceLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseProton Magnetic Resonance SpectroscopyROC CurveRegression AnalysisTriglyceridesWhite PeopleYoung Adultresearch article28445310open access10.1097/MD.00000000000067701536-5964PMC5413275https://doi.org/10.1097/md.0000000000006770https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413275/pdf