Zafrir, BarakLund, Lars HLaroche, CecileRuschitzka, FrankCrespo-Leiro, Maria GCoats, Andrew J SAnker, Stefan DFilippatos, GerasimosSeferovic, Petar MMaggioni, Aldo PDe-Mora-Martin, ManuelPolonski, LechSilva-Cardoso, JoseAmir, Offer2023-01-252023-01-252018-10-15Zafrir B, Lund LH, Laroche C, Ruschitzka F, Crespo-Leiro MG, Coats AJS, et al. Prognostic implications of atrial fibrillation in heart failure with reduced, mid-range, and preserved ejection fraction: a report from 14 964 patients in the European Society of Cardiology Heart Failure Long-Term Registry. Eur Heart J. 2018 Dec 21;39(48):4277-4284http://hdl.handle.net/10668/13090To investigate the characteristics long-term prognostic implications (up to ∼2.2 years) of atrial fibrillation (AF) compared to sinus rhythm (SR), between acute and chronic heart failure (HF) with reduced (HFrEF  Data from the observational, prospective, HF long-term registry of the European Society of Cardiology were analysed. A total of 14 964 HF patients (age 66 ± 13 years, 67% male; 53% HFrEF, 21% HFmrEF, 26% HFpEF) were enrolled. The prevalence of AF was 27% in HFrEF, 29% in HFmrEF, and 39% in HFpEF. Atrial fibrillation was associated with older age, lower functional capacity, and heightened physical signs of HF. Crude rates of mortality and HF hospitalization were higher in patients with AF compared to SR, in each EF subtype. After multivariable adjustment, the hazard ratio of AF for HF hospitalizations was: 1.036 (95% CI 0.888-1.208, P = 0.652) in HFrEF, 1.430 (95% CI 1.087-1.882, P = 0.011) in HFmrEF, and 1.487 (95% CI 1.195-1.851, P  The prevalence of AF increases with increasing EF but its association with worse cardiovascular outcomes, remained significant in patients with HFpEF and HFmrEF, but not in those with HFrEF.enHeart failureAtrial fibrillationHospitalizationsMortalityEjection fractionPrognosisAgedAtrial FibrillationCardiologyCause of DeathEuropeFemaleHeart FailureHospitalizationHumansMaleMiddle AgedPrevalencePrognosisProspective StudiesSocieties, MedicalStroke Volumeresearch article30325423Restricted AccessPrevalenciaFibrilación atrialHospitalizaciónInsuficiencia cardíacaCardiologíaAdaptación psicológica10.1093/eurheartj/ehy6261522-9645https://academic.oup.com/eurheartj/article-pdf/39/48/4277/27206071/ehy626.pdf