Li, ChenStoma, SvetlanaLotta, Luca AWarner, SophieAlbrecht, EvaAllione, AlessandraArp, Pascal PBroer, LindaBuxton, Jessica LDa Silva Couto Alves, AlexessanderDeelen, JorisFedko, Iryna OGordon, Scott DJiang, TaoKarlsson, RobertKerrison, NicolaLoe, Taylor KMangino, MassimoMilaneschi, YuriMiraglio, BenjaminPervjakova, NataliaRusso, AlessiaSurakka, Idavan der Spek, AshleyVerhoeven, Josine EAmin, NajafBeekman, MarianBlakemore, Alexandra ICanzian, FedericoHamby, Stephen EHottenga, Jouke-JanJones, Peter DJousilahti, PekkaMägi, ReedikMedland, Sarah EMontgomery, Grant WNyholt, Dale RPerola, MarkusPietiläinen, Kirsi HSalomaa, VeikkoSillanpää, ElinaSuchiman, H Ekavan Heemst, DianaWillemsen, GonnekeAgudo, AntonioBoeing, HeinerBoomsma, Dorret IChirlaque, Maria-DoloresFagherazzi, GuyFerrari, PietroFranks, PaulGieger, ChristianEriksson, Johan GunnarGunter, MarcHägg, SaraHovatta, IirisImaz, LiherKaprio, JaakkoKaaks, RudolfKey, TimothyKrogh, VittorioMartin, Nicholas GMelander, OlleMetspalu, AndresMoreno, ConchaOnland-Moret, N CharlotteNilsson, PeterOng, Ken KOvervad, KimPalli, DomenicoPanico, SalvatorePedersen, Nancy LPenninx, Brenda W J HQuiros, J RamonJarvelin, Marjo RiittaRodriguez-Barranco, MiguelScott, Robert ASeveri, GianlucaSlagboom, P ElineSpector, Tim DTjonneland, AnneTrichopoulou, AntoniaTumino, RosarioUitterlinden, André Gvan der Schouw, Yvonne Tvan Duijn, Cornelia MWeiderpass, ElisabeteDenchi, Eros LazzeriniMatullo, GiuseppeButterworth, Adam SDanesh, JohnSamani, Nilesh JWareham, Nicholas JNelson, Christopher PLangenberg, ClaudiaCodd, Veryan2023-02-082023-02-082020-02-10Li C, Stoma S, Lotta LA, Warner S, Albrecht E, Allione A, et al. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet. 2020 Mar 5;106(3):389-404.http://hdl.handle.net/10668/15179Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) 350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Mendelian randomisationage-related diseasebiological agingtelomere lengthGenome-Wide Association StudyHumansLeukocytesNucleotidesTelomereresearch article32109421open accessTelómeroNucleótidosLeucocitosHumanosEstudio de asociación del genoma completo10.1016/j.ajhg.2020.02.0061537-6605PMC7058826http://www.cell.com/article/S0002929720300483/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058826/pdf