Huyghe, Jeroen RBien, Stephanie AHarrison, Tabitha AKang, Hyun MinChen, SaiSchmit, Stephanie LConti, David VQu, ConghuiJeon, JihyounEdlund, Christopher KGreenside, PeytonWainberg, MichaelSchumacher, Fredrick RSmith, Joshua DLevine, David MNelson, Sarah CSinnott-Armstrong, Nasa AAlbanes, DemetriusAlonso, M HenarAnderson, KristinArnau-Collell, CoralArndt, VolkerBamia, ChristinaBanbury, Barbara LBaron, John ABerndt, Sonja IBézieau, StéphaneBishop, D TimothyBoehm, JuergenBoeing, HeinerBrenner, HermannBrezina, StefanieBuch, StephanBuchanan, Daniel DBurnett-Hartman, AndreaButterbach, KatjaCaan, Bette JCampbell, Peter TCarlson, Christopher SCastellví-Bel, SergiChan, Andrew TChang-Claude, JennyChanock, Stephen JChirlaque, Maria-DoloresCho, Sang HeeConnolly, Charles MCross, Amanda JCuk, KatarinaCurtis, Keith Rde la Chapelle, AlbertDoheny, Kimberly FDuggan, DavidEaston, Douglas FElias, Sjoerd GElliott, FayeEnglish, Dallas RFeskens, Edith J MFigueiredo, Jane CFischer, RockyFitzGerald, Liesel MForman, DavidGala, ManishGallinger, StevenGauderman, W JamesGiles, Graham GGillanders, ElizabethGong, JianGoodman, Phyllis JGrady, William MGrove, John SGsur, AndreaGunter, Marc JHaile, Robert WHampe, JochenHampel, HeatherHarlid, SophiaHayes, Richard BHofer, PhilippHoffmeister, MichaelHopper, John LHsu, Wan-LingHuang, Wen-YiHudson, Thomas JHunter, David JIbañez-Sanz, GemmaIdos, Gregory EIngersoll, RoxannJackson, Rebecca DJacobs, Eric JJenkins, Mark AJoshi, Amit DJoshu, Corinne EKeku, Temitope OKey, Timothy JKim, Hyeong RokKobayashi, EmikoKolonel, Laurence NKooperberg, CharlesKühn, TilmanKüry, SébastienKweon, Sun-SeogLarsson, Susanna CLaurie, Cecelia ALe Marchand, LoicLeal, Suzanne MLee, Soo ChinLejbkowicz, FlavioLemire, MathieuLi, Christopher ILi, LiLieb, WolfgangLin, YiLindblom, AnnikaLindor, Noralane MLing, HuaLouie, Tin LMännistö, SatuMarkowitz, Sanford DMartín, VicenteMasala, GiovannaMcNeil, Caroline EMelas, MarilenaMilne, Roger LMoreno, LorenaMurphy, NeilMyte, RobinNaccarati, AlessioNewcomb, Polly AOffit, KennethOgino, ShujiOnland-Moret, N CharlottePardini, BarbaraParfrey, Patrick SPearlman, RachelPerduca, VittorioPharoah, Paul D PPinchev, MilaPlatz, Elizabeth APrentice, Ross LPugh, ElizabethRaskin, LeonRennert, GadRennert, Hedy SRiboli, ElioRodríguez-Barranco, MiguelRomm, JaneSakoda, Lori CSchafmayer, ClemensSchoen, Robert ESeminara, DanielaShah, MitulShelford, TamekaShin, Min-HoShulman, KaterinaSieri, SabinaSlattery, Martha LSouthey, Melissa CStadler, Zsofia KStegmaier, ChristaSu, Yu-RuTangen, Catherine MThibodeau, Stephen NThomas, Duncan CThomas, Sushma SToland, Amanda ETrichopoulou, AntoniaUlrich, Cornelia MVan Den Berg, David Jvan Duijnhoven, Franzel J BVan Guelpen, Bethanyvan Kranen, HenkVijai, JosephVisvanathan, KalaVodicka, PavelVodickova, LudmilaVymetalkova, VeronikaWeigl, KorbinianWeinstein, Stephanie JWhite, EmilyWin, Aung KoWolf, C RolandWolk, AlicjaWoods, Michael OWu, Anna HZaidi, Syed HZanke, Brent WZhang, QingZheng, WeiScacheri, Peter CPotter, John DBassik, Michael CKundaje, AnshulCasey, GrahamMoreno, VictorAbecasis, Goncalo RNickerson, Deborah AGruber, Stephen BHsu, LiPeters, Ulrike2023-01-252023-01-252018-12-03http://hdl.handle.net/10668/13276To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P enAgedCase-Control StudiesColorectal NeoplasmsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRNA, Long NoncodingRisk FactorsSignal Transductionresearch article30510241open access10.1038/s41588-018-0286-61546-1718PMC6358437https://europepmc.org/articles/pmc6358437?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437/pdf