Chaparro, MariaGarre, AnaNuñez Ortiz, AndreaDiz-Lois Palomares, Maria TeresaRodriguez, CristinaRiestra, SabinoVela, MilagrosBenitez, Jose ManuelFernandez Salgado, EstelaSanchez Rodriguez, EugeniaHernandez, VicentFerreiro-Iglesias, RocioPonferrada Díaz, AngelBarrio, JesusHuguet, Jose MariaSicilia, BeatrizMartin-Arranz, Maria DoloresCalvet, XavierGinard, DanielAlonso-Abreu, InmaculadaFernandez-Salazar, LuisVarela Trastoy, PilarRivero, MontserratVera-Mendoza, IsabelVega, PabloNavarro, PabloSierra, MonicaCabriada, Jose LuisAguas, MariamVicente, RaquelNavarro-Llavat, MerceEcharri, AnaGomollon, FernandoGuerra Del Rio, ElenaPiñero, ConcepcionCasanova, Maria JoseSpicakova, KaterinaOrtiz de Zarate, JoneTorrella Cortes, EmilioGutierrez, AnaAlonso-Galan, HoracioHernandez-Martinez, AlvaroMarrero, Jose MiguelLorente Poyatos, RufoCalafat, MargalidaMarti Romero, LidiaRobledo, PilarBosch, OrencioJimenez, NuriaEsteve Comas, MariaDuque, Jose MariaFuentes Coronel, Ana MariaJosefa Sampedro, ManuelaSese Abizanda, EvaHerreros Martinez, BelenPozzati, LilianaFernandez Rosaenz, HipolitoCrespo Suarez, BelenLopez Serrano, PilarLucendo, Alfredo JMuñoz Vicente, MargaritaBermejo, FernandoRamirez Palanca, Jose JoaquinMenacho, MargaritaCarmona, AmaliaCamargo, RaquelTorra Alsina, SandraMaroto, NuriaNerin de la Puerta, JuanCastro, ElenaMarin-Jimenez, IgnacioBotella, BelenSapiña, AmparoCruz, NoeliaForcelledo, Jose Luis FBouhmidi, AbdelCastaño-Milla, CarlosOpio, VeronicaNicolas, IsabelKutz, MarcosAbraldes Bechiarelli, AlfredoGordillo, JordiBer, YolandaTorres Dominguez, YolandaNovella Duran, Maria TeresaRodriguez Mondejar, SilviaMartinez-Cerezo, Francisco JKolle, LilyanSabat, MiriamLedezma, CesarIyo, EduardoRoncero, OscarIrisarri, RebecaLluis, LaiaBlazquez Gomez, IsabelZapata, Eva MariaJose Alcala, MariaMartinez Pascual, CristinaMontealegre, MariaMata, LauraMonrobel, AnaHernandez Camba, AlejandroHernandez, LuisTejada, MariaMir, AlbertoGalve, Maria LuisaSoler, MartaHervias, DanielGomez-Valero, Jose AntonioBarreiro-de Acosta, ManuelRodriguez-Artalejo, FernandoGarcia-Esquinas, EstherGisbert, Javier P2023-02-092023-02-092021-06-15Chaparro M, Garre A, Núñez Ortiz A, Diz-Lois Palomares MT, Rodríguez C, Riestra S, et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J Clin Med. 2021 Jun 29;10(13):2885. doi: 10.3390/jcm10132885. Erratum in: J Clin Med. 2022 Sep 30;11(19):58162077-0383http://hdl.handle.net/10668/18136Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p< 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Crohn’s diseaseEpidemiologyIncidenceInflammatory bowel diseaseUlcerative colitisChild, preschoolColitis, ulcerativeProspective studiesInflammatory bowel diseasesImmunologic factorsBiological productsHospitalsSteroidsResearch article34209680open accessColitis ulcerosaEnfermedades inflamatorias del intestinoEsteroidesFactores inmunológicosHospitalesPreescolarProductos biológicosSistema de registros10.3390/jcm10132885PMC8268420https://www.mdpi.com/2077-0383/10/13/2885/pdf?version=1664537042https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268420/pdf