Lavilla Olleros, CristinaAusín García, CristinaBendala Estrada, Alejandro DavidMuñoz, AnaWikman Jogersen, Philip ErickFernández Cruz, AnaGiner Galvañ, VicenteVargas, Juan AntonioSeguí Ripoll, José MiguelRubio-Rivas, ManuelMiranda Godoy, RodrigoMérida Rodrigo, LuisFonseca Aizpuru, EvaArnalich Fernández, FranciscoArtero, ArturoLoureiro Amigo, JoseGarcía García, Gema MaríaCorral Gudino, LuisJiménez Torres, JoseCasas-Rojo, José-ManuelMillán Núñez-Cortés, JesúsSEMI-COVID-19 Network2023-05-032023-05-032022-01-21http://hdl.handle.net/10668/20414To describe the impact of different doses of corticosteroids on the evolution of patients with COVID-19 pneumonia, based on the potential benefit of the non-genomic mechanism of these drugs at higher doses. Observational study using data collected from the SEMI-COVID-19 Registry. We evaluated the epidemiological, radiological and analytical scenario between patients treated with megadoses therapy of corticosteroids vs low-dose of corticosteroids and the development of complications. The primary endpoint was all-cause in-hospital mortality according to use of corticosteroids megadoses. Of a total of 14,921 patients, corticosteroids were used in 5,262 (35.3%). Of them, 2,216 (46%) specifically received megadoses. Age was a factor that differed between those who received megadoses therapy versus those who did not in a significant manner (69 years [IQR 59-79] vs 73 years [IQR 61-83]; p There is no difference in mortality with megadoses versus low-dose, but there is a lower incidence of infectious complications with glucocorticoid megadoses.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Adrenal Cortex HormonesAdultAge FactorsAgedAged, 80 and overCOVID-19Drug Administration ScheduleFemaleHospital MortalityHumansMaleMiddle AgedPrednisoneRegistriesSARS-CoV-2SepsisSpainSurvival AnalysisTreatment OutcomeCOVID-19 Drug Treatmentresearch article35061713open access10.1371/journal.pone.02617111932-6203PMC8782507https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261711&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782507/pdf