Flores-Martinez, ÁlvaroVenegas-Moreno, EvaDios, ElenaRemón-Ruiz, PabloGros-Herguido, NoeliaVázquez-Borrego, M. CarmenMadrazo-Atutxa, AinaraJapón, Miguel A.Kaen, ArielCárdenas-Valdepeñas, EugenioRoldán, FlorindaCastaño, Justo P.Luque, Raúl M.Cano, David A.Soto-Moreno, Alfonso2022-12-292022-12-292020-09-22Flores-Martinez Á, Venegas-Moreno E, Dios E, Remón-Ruiz P, Gros-Herguido N, Vázquez-Borrego MC, et al. Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features. J Clin Med. 2020 Sep 22;9(9):3052http://hdl.handle.net/10668/4545The primary treatment for non-functioning pituitary tumors (NFPTs) is surgery, but it is often unsuccessful. Previous studies have reported that NFPTs express receptors for somatostatin (SST1-5) and dopamine (DRDs) providing a rationale for the use of dopamine agonists and somatostatin analogues. Here, we systematically assessed SST1-5 and DRDs expression by real-time quantitative PCR (RT-qPCR) in a large group of patients with NFPTs (n = 113) and analyzed their potential association with clinical and molecular aggressiveness features. SST1-5 expression was also evaluated by immunohistochemistry. SST3 was the predominant SST subtype detected, followed by SST2, SST5, and SST1. DRD2 was the dominant DRD subtype, followed by DRD4, DRD5, and DRD1. A substantial proportion of NFPTs displayed marked expression of SST2 and SST5. No major association between SSTs and DRDs expression and clinical and molecular aggressiveness features was observed in NFPTs.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Pituitary tumorInvasionSomatostatin receptorDopamine receptorNon-functioning pituitary tumorsDopamine agonistsNeoplasias hipofisariasReceptores de somatostatinaReceptores dopaminérgicosAgonistas de dopaminaAndalucíaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Dopamine Agents::Dopamine AgonistsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::ImmunohistochemistryMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pituitary NeoplasmsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain ReactionMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spainresearch article32971845open access10.3390/jcm90930522077-0383PMC7565399