Helmy, RemonScalso de Almeida, SamiraDenhaerynck, KrisBerben, LutDobbels, FabienneRussell, Cynthia Lde Aguiar Roza, BartiraDe Geest, SabinaBRIGHT study team2023-01-252023-01-252018-12-24http://hdl.handle.net/10668/13363To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. MNA was significantly (α = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). The observed MNA necessitates adherence-enhancing interventions encompassing the entire post-heart transplant medication regimen. ClinicalTrials.gov identifier: NCT01608477.enco-medicationscross-sectionalheart transplantationimmunosuppressantsinternationalmedication adherenceAdultAgedCross-Sectional StudiesFemaleHeart TransplantationHumansImmunosuppressive AgentsLogistic ModelsMaleMedication AdherenceMiddle AgedPrevalenceSelf Reportresearch article30591285open access10.1016/j.clinthera.2018.11.0071879-114Xhttps://lirias.kuleuven.be/bitstream/123456789/635630/2/2019%20Helmy%20et%20al.%20Clinical%20Therapeutics%20BRIGHT%20study%20co%20medications%20immunosuppressants.pdf