Dicanio, MarcoGiaccherini, MatteoClay-Gilmour, AlyssaMacauda, AngelicaSainz, JuanMachiela, Mitchell JRybicka-Ramos, MalwinaNorman, Aaron DTyczyńska, AgataChanock, Stephen JBarington, TorbenKumar, Shaji KBhatti, ParveenCozen, WendyBrown, Elizabeth ESuska, AnnaHaastrup, Eva KOrlowski, Robert ZDudziński, MarekGarcia-Sanz, RamonKruszewski, MarcinMartinez-Lopez, JoaquinBeider, KatiaIskierka-Jazdzewska, ElżbietaPelosini, MatteoBerndt, Sonja IRaźny, MałgorzataJamroziak, KrzysztofRajkumar, S VincentJurczyszyn, ArturVangsted, Annette JuulCollado, Pilar GarridoVogel, UllaHofmann, Jonathan NPetrini, MarioButrym, AleksandraSlager, Susan LZiv, EladSubocz, EdytaGiles, Graham GAndersen, Niels FrostMazur, GrzegorzWatek, MarzenaLesueur, FabienneHildebrandt, Michelle A TZawirska, DariaEbbesen, Lene HyldahlMarques, HerlanderGemignani, FedericaDumontet, CharlesVárkonyi, JuditBuda, GabrieleNagler, ArnonDruzd-Sitek, AgnieszkaWu, XifengKadar, KatalinCamp, Nicola JGrzasko, NorbertWaller, Rosalie GVachon, CelineCanzian, FedericoCampa, Daniele2023-05-032023-05-032022-10-01http://hdl.handle.net/10668/22106Pleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome-wide significant loci shared across cancer and noncancer traits. This feature is particularly relevant in multiple myeloma (MM) because several susceptibility loci that have been identified to date are pleiotropic. Therefore, the aim of this study was to identify novel pleiotropic variants involved in MM risk using 28 684 independent single nucleotide polymorphisms (SNPs) from GWAS Catalog that reached a significant association (P enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/genetic susceptibilitymultiple myelomapleiotropypleiotropy scanpolymorphismsHumansMultiple MyelomaOncogenesAllelesPhenotypePolymorphism, Single NucleotideGenome-Wide Association StudyGenetic Predisposition to DiseaseHSP40 Heat-Shock ProteinsDNA-Binding ProteinsRNA-Binding Proteinsresearch article36082445open access10.1002/ijc.342781097-0215PMC9828677https://findresearcher.sdu.dk/ws/files/219032255/Intl_Journal_of_Cancer_2022_Dicanio_A_pleiotropic_variant_in_DNAJB4_is_associated_with_multiple_myeloma_risk.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828677/pdf