Raigon Ponferrada, AidaGuerrero Orriach, Jose LuisMalo Manso, AlfredoSepúlveda Haro, EnriqueRomero Molina, SalvadorFontaneda Heredia, AnaBaena Lopez, ManoloCruz Mañas, Jose2022-08-312022-08-312020-07-27Ponferrada AR, Orriach JLG, Manso AM, Haro ES, Molina SR, Heredia AF, et al. Anaesthesia and cancer: can anaesthetic drugs modify gene expression? Ecancermedicalscience. 2020 Jul 27;14:1080http://hdl.handle.net/10668/3969Cancer remains a primary cause of morbidity and mortality worldwide, and its incidence continues to increase. The most common cause of death in cancer patients is tumour recurrence. Surgery is the gold standard in the treatment of most tumours. However, cancer surgery can lead to the release of tumour cells into the systemic circulation. Surgical stress and several perioperative factors have been suggested to boost tumour growth, thereby increasing the risk of metastatic recurrence. Preclinical and clinical studies suggest that anaesthetics and adjuvants administered during the perioperative period may impact cancer recurrence and survival. This document summarises the current evidence regarding the effects of anaesthetic drugs and analgesic techniques on the immune system, systemic inflammatory response and tumour cells, as well as their impact on cancer recurrence.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/AnaesthesiaAnalgesiaCancer recurrenceMetastasesAnaestheticsRegional anaesthesiaOpioidNSAIDsAnestesia en procedimientos quirúrgicos cardíacosMetástasis de la neoplasiaAnalgésicos opioidesAntiinflamatorios no esteroideosMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, LocalMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Cause of DeathMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::IncidenceMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Central Nervous System Depressants::AnestheticsMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::AnalgesicsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Perioperative PeriodMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Shock::Systemic Inflammatory Response SyndromeMedical Subject Headings::Anatomy::Hemic and Immune Systems::Immune SystemMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Anesthesia and Analgesia::Anesthesia::Anesthesia, ConductionMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expressionresearch article32863874open access10.3332/ecancer.2020.10801754-6605PMC7434501