de la Cruz-Ares, SilviaLeon-Acuña, AnaYubero-Serrano, Elena MTorres-Peña, Jose DArenas-de Larriva, Antonio PCardelo, Magdalena PRangel-Zuñiga, Oriol ALuque, Raul MAlcala-Diaz, Juan FOrdovas, Jose MPerez-Martinez, PabloLopez-Miranda, JoseDelgado-Lista, Javier2023-05-032023-05-032022-06-03de la Cruz-Ares S, Leon-Acuña A, Yubero-Serrano EM, Torres-Peña JD, Arenas-de Larriva AP, Cardelo MP, et al. High density lipoprotein subfractions and extent of coronary atherosclerotic lesions: From the cordioprev study. Clin Chim Acta. 2022 Aug 1;533:89-95http://hdl.handle.net/10668/22074The extent of atherosclerotic coronary heart disease (CHD) is associated with its prognosis, thus discovering potential biomarkers related to worse outcomes could prove valuable. The present work aims to investigate whether lipoprotein subfractions are associated with angiographic CHD severity. Patients from the CORDIOPREV study exhibiting coronary lesions in angiography were classified into two groups (single-vessel coronary disease (SVD) or multivessel coronary disease (MVD)). High-throughput nuclear magnetic resonance (NMR) spectroscopy determined lipoprotein subfractions concentration and composition. SVD patients showed a higher concentration of medium and small HDL particles compared with MVD patients. For medium HDL, total lipids, phospholipids, total cholesterol, cholesteryl esters and free cholesterol reflected HDL particle concentration, whereas, for small HDL, total lipids, phospholipids, and free cholesterol mirrored lipoprotein particle concentration. Among traditional cardiovascular risk factors, age, hypertension and T2D were independently associated with angiography severity. In multivariate logistic regression models, medium and small HDL particles remained inversely associated with angiography severity (OR 0.77 (95% CI: 0.64-0.91); OR 0.78 (95% CI: 0.67-0.91), respectively) after adjusting with covariates. In CHD patients mostly on statin treatment, angiography severity is inversely related to small and medium HDL subclasses concentration measured by NMR. These particles are also independent predictors of the presence of MVD, and its use increased the prediction of this entity over traditional risk factors.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Angiography severityAtherosclerosisCardiovascular risk factorsHDL particlesLipoprotein subfractionsAtherosclerosisCholesterolCholesterol, HDLCoronary artery diseaseHumansLipoproteinsLipoproteins, HDLResearch article35700819open accessAterosclerosisColesterolEnfermedad de la arteria coronariaHDL-colesterolHumanosLipoproteínasLipoproteínas HDL10.1016/j.cca.2022.06.0021873-3492https://doi.org/10.1016/j.cca.2022.06.002