Marcuello, C.Calle-Pascual, A.L.Fuentes, M.Runkle, I.Soriguer, F.Goday, A.Bosch-Comas, A.Bordiú, E.Carmena, R.Casamitjana, R.Castaño, L.Castell, C.Catalá, M.Delgado, E.Franch, J.Gaztambide, S.Girbés, J.Gomis, R.Gutiérrez, G.López-Alba, A.Martínez-Larrad, M.T.Menéndez, E.Mora-Peces, I.Ortega, E.Pascual-Manich, G.Rojo-Martínez, G.Serrano-Rios, M.Valdés, S.Vázquez, J.A.Vendrell, J.2014-02-042014-02-042012Marcuello C, Calle-Pascual AL, Fuentes M, Runkle I, Soriguer F, Goday A, et al. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study (Di@bet.es Study). Int J Endocrinol. 2012: 2012; 872305. doi:10.1155/2012/8723051687-8337http://hdl.handle.net/10668/1487Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population. Methods. A population-based, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12 questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted. Results. Mean PCS-12/MCS-12 values were 50.9 ± 8.5/47.6 ± 10.2, respectively. Men had higher scores than women in both PCS-12 (51.8 ± 7.2 versus 50.3 ± 9.2; P < 0.001) and MCS-12 (50.2 ± 8.5 versus 45.5 ± 10.8; P < 0.001). Increasing age and obesity were associated with a poorer PCS-12 score. In women lower PCS-12 and MCS-12 scores were associated with a higher level of glucose metabolism abnormality (prediabetes and diabetes), (P < 0.0001 for trend), but only the PCS-12 score was associated with altered glucose levels in men (P < 0.001 for trend). The Odds Ratio adjusted for age, body mass index (BMI) and educational level, for a PCS-12 score below the median was 1.62 (CI 95%: 1.2–2.19; P < 0.002) for men with KDM and 1.75 for women with KDM (CI 95%: 1.26–2.43; P < 0.001), respectively. Conclusion. Current study indicates that increasing levels of altered carbohydrate metabolism are accompanied by a trend towards decreasing quality of life, mainly in women, in a representative sample of Spanish population.esEspañaCalidad de VidaEstudios TransversalesMuestreoAnálisis de RegresiónModelos LogísticosMetabolismo de los Hidratos de CarbonoGlucosaMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes MellitusMedical Subject Headings::Disciplines and Occupations::Social Sciences::Quality of LifeMedical Subject Headings::Geographicals::Geographic Locations::Europe::SpainMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional StudiesMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Sampling StudiesMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Carbohydrate MetabolismMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression AnalysisMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis::Logistic ModelsMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::GlucoseMedical Subject Headings::Named Groups::Persons::MenMedical Subject Headings::Named Groups::Persons::WomenMedical Subject Headings::Named Groups::Persons::Age Groups::Adultresearch article22848215open access10.1155/2012/8723051687-8345PMC3405659