A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.

Gómez-González, BelenSessa, GaetanaCarreira, AuraAguilera, Andrés2023-02-092023-02-092021-04-142372-3556http://hdl.handle.net/10668/17824In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.enBRCA2DDX5DNA-RNA hybridDSB repairbreast cancerdouble-strand breakhomologous recombinationA new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.research article34027046open access10.1080/23723556.2021.1910474PMC8128217https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128217https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128217/pdf