Rodriguez-Barranco, MSalamanca-Fernandez, EFajardo, M LBayo, EChang-Chan, Y-LExposito, JGarcia, CTallon, JMinicozzi, PSant, MPetrova, DLuque-Fernandez, M ASanchez-Perez, Maria-Jose2023-01-252023-01-252018-10-08Rodríguez-Barranco M, Salamanca-Fernández E, Fajardo ML, Bayo E, Chang-Chan YL, Expósito J, et al. Patient, tumor, and healthcare factors associated with regional variability in lung cancer survival: a Spanish high-resolution population-based study. Clin Transl Oncol. 2019 May;21(5):621-629.http://hdl.handle.net/10668/13110The third most frequently diagnosed cancer in Europe in 2018 was lung cancer; it is also the leading cause of cancer death in Europe. We studied patient and tumor characteristics, and patterns of healthcare provision explaining regional variability in lung cancer survival in southern Spain. A population-based cohort study included all 1196 incident first invasive primary lung cancer (C33-C34 according to ICD-10) cases diagnosed between 2010 and 2011 with follow-up until April 2015. Data were drawn from local population-based cancer registries and patients' hospital medical records from all public and private hospitals from two regions in southern Spain. There was evidence of regional differences in lung cancer late diagnosis (58% stage IV in Granada vs. 65% in Huelva, p value  The observed geographic differences in survival between regions are due in part to the late cancer diagnosis which determines the use of less effective therapeutic options. Results from our study justify the need for promoting lung cancer early detection strategies and the harmonization of the best practice in lung cancer management and treatment.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cancer treatmentExcess riskHospital medical recordsLung cancerPopulation-based cancer epidemiologySurvival analysisAdolescentAdultAgedCohort StudiesCombined Modality TherapyEarly Detection of CancerFemaleFollow-Up StudiesHealth ServicesHealthcare DisparitiesHumansLung NeoplasmsMaleMiddle AgedPrognosisRegistriesRisk FactorsSpainSurvival RateYoung Adultresearch article30341474open accessDetección precoz del cáncerEstudios de cohortesNeoplasias pulmonaresTasa de supervivenciaTerapia combinada10.1007/s12094-018-1962-91699-3055https://link.springer.com/content/pdf/10.1007/s12094-018-1962-9.pdf