Torres-Aguila, Nuria PCarrera, CatyGiese, Anne-KatrineCullell, NataliaMuiño, ElenaCárcel-Márquez, JaraGallego-Fabrega, CristinaGonzález-Sánchez, JonathanDel Mar Freijo, MaríaÁlvarez-Sabín, JoséMolina, CarlosRibó, MarcJimenez-Conde, JordiRoquer, JaumeSobrino, TomásCampos, FranciscoCastillo, JoséMuñoz-Narbona, LuciaLopez-Cancio, ElenaDàvalos, AntoniDiaz-Navarro, RosaTur, SilviaVives-Bauza, CristòfolSerrano-Heras, GemmaSegura, TomásKrupinski, JerzyDelgado-Mederos, RaquelMartí-Fàbregas, JoanHeitsch, LauraIbañez, LauraCruchaga, CarlosRost, Natalia SMontaner, JoanLee, Jin-MooFernandez-Cadenas, Israel2023-01-252023-01-252019-10-07http://hdl.handle.net/10668/14589Background and Purpose- Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke. Methods- Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed. Results- Our genome-wide association study, which included 2064 (Discovery) and 407 (Replication) patients, revealed a new locus (14q24.3) associated with leukocyte counts. After Joint analysis (n=2471) 5 more polymorphisms reached genome-wide significance (Pengenome-wide association studyhumansleukocytesrisk factorsstrokeAgedAged, 80 and overBrain IschemiaChromosomes, Human, Pair 14FemaleGenome-Wide Association StudyHumansLeukocyte CountLeukocytesMaleMiddle AgedPolymorphism, Single NucleotidePrognosisStrokeresearch article31587654open access10.1161/STROKEAHA.119.0265931524-4628PMC6878188https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.119.026593https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878188/pdf