Hassoun-Kheir, Nasreenvan-Werkhoven, C HenriDunning, JakeJaenisch, Thomasvan-Beek, JankoBielicki, JuliaButler, Christopher CFrancois, BrunoHarbarth, StephanHernandez Padilla, Ana CHorby, PeterKoopmans, MarionLee, JamesRodriguez-Baño, JesusTacconelli, EvelinaThemistocleous, Yrenevan-der-Velden, Alike WBonten, MarcGoossens, Hermande-Kraker, Marlieke E A2023-05-032023-05-032022-12Hassoun-Kheir N, van Werkhoven CH, Dunning J, Jaenisch T, van Beek J, Bielicki J, et al. Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases. Clin Microbiol Infect. 2022 Dec;28(12):1528-1532.http://hdl.handle.net/10668/22135Emerging infectious diseases are a growing threat, through population growth , increased trade and travel , urbanization , deforestation , and climate change [1]. Clinical research in response to emerging infectious diseases is challenging; selecting and contracting the appropriate study sites for a trial is time consuming, and often too few patients can be timely recruited to acquire high-quality evidence about the best treatment strategies [2]. In 2014, the EU-funded PREPARE project (Platform foR European Preparedness Against (Re-)emerging Epidemics ) was initiated to rapidly respond to severe infectious diseases outbreaks . It initiated two adaptive platform trials, the REMAP-CAP [3] and the ALIC4E trial [4], determining the effectiveness of multiple treatment strategies for a single disease . The REMAP-CAP trial was designed for a pandemic of severe community-acquired pneumonia and expanded globally during the COVID-19 pandemic. It has already delivered 10 important conclusions for better treatment of COVID-19 [3].enAtribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Antimicrobial resistanceEmerging infectious diseasesPerpetual observational studiesResearch networkStudy methodologyHumansRandomized Controlled Trials as TopicCommunicable Diseasesresearch article35940566open accessTerapéuticaCrecimiento demográficoNeumonía adquirida en la comunidadEpidemiasPreparación ante desastresBrotes de enfermedadesPandemias10.1016/j.cmi.2022.07.0241469-0691PMC9354481https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354481https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354481/pdf