Gauthier, Benoit R.Sola-García, AlejandroCáliz-Molina, María ÁngelesLorenzo, Petra IsabelCobo-Vuilleumier, NadiaCapilla-González, VivianMartin-Montalvo, Alejandro2022-05-032022-05-032020Gauthier BR, Sola-García A, Cáliz-Molina MÁ, Lorenzo PI, Cobo-Vuilleumier N, Capilla-González V, et al. Thyroid hormones in diabetes, cancer, and aging. Aging Cell. 2020 Nov;19(11):e13260http://hdl.handle.net/10668/3606Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and human research have determined that thyroid hormones modulate cellular processes relevant for aging and for the majority of age-related diseases. While several studies have associated mild reductions on thyroid hormone function with exceptional longevity in animals and humans, alterations in thyroid hormones are serious medical conditions associated with unhealthy aging and premature death. Moreover, both hyperthyroidism and hypothyroidism have been associated with the development of certain types of diabetes and cancers, indicating a great complexity of the molecular mechanisms controlled by thyroid hormones. In this review, we describe the latest findings in thyroid hormone research in the field of aging, diabetes, and cancer, with a special focus on hepatocellular carcinomas. While aging studies indicate that the direct modulation of thyroid hormones is not a viable strategy to promote healthy aging or longevity and the development of thyromimetics is challenging due to inefficacy and potential toxicity, we argue that interventions based on the use of modulators of thyroid hormone function might provide therapeutic benefit in certain types of diabetes and cancers.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/CancerDiabetesHealth spanHyperthyroidismHypothyroidismLife spanThyroid hormonesNeoplasiasDiabetes mellitusHipertiroidismoHipotiroidismoLongevidadHormonas tiroideasMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::AgingMedical Subject Headings::Diseases::Endocrine System Diseases::Diabetes MellitusMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk FactorsMedical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Thyroid GlandMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid HormonesMedical Subject Headings::Diseases::Endocrine System Diseases::Thyroid Diseases::HypothyroidismMedical Subject Headings::Diseases::Endocrine System Diseases::Thyroid Diseases::HyperthyroidismMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Longevityreview article33048427Acceso abierto10.1111/acel.132601474-9726PMC7681062