Zhou, LisaLeonard, AlexandraPavel, Ana BMalik, KunalRaja, AishwaryaGlickman, JacobEstrada, Yeriel DPeng, XiangyuDel Duca, EsterSanz-Cabanillas, JuanRuano, JuanXu, HuiZhang, NingWen, Huei-ChiGonzalez, JuanaGarcet, SandraKrueger, James GGuttman-Yassky, Emma2023-01-252023-01-252019-01-24http://hdl.handle.net/10668/13466Atopic dermatitis (AD) shows differential clinical presentation in older compared with younger patients. Nevertheless, changes in the AD molecular profile with age are unknown. We sought to characterize age-related changes in the AD profile. We evaluated age-specific changes in lesional and nonlesional tissues and blood from patients with moderate-to-severe AD (n = 246) and age-matched control subjects (n = 71) using immunohistochemistry, quantitative real-time PCR, and Singulex in a cross-sectional study. Patients were analyzed by age group (18-40, 41-60, and ≥61 years). Although disease severity/SCORAD scores were similar across AD age groups (mean, approximately 60 years; P = .873), dendritic cell infiltrates (CD1b+ and FcεRI+, P  The adult AD profile varies with age. Although TH1/TH17 skewing increases in both patients with AD and control subjects, patients with AD show unique decreases in TH2/TH22 polarization and normalization of epithelial abnormalities. Thus age-specific treatment approaches might be beneficial for AD.enAtopic dermatitisT(H)1T(H)17T(H)2T(H)22agingbiomarkerfilaggrinhyperplasialoricrinskinAdolescentAdultAgedAged, 80 and overAgingCytokinesDermatitis, AtopicFemaleFilaggrin ProteinsGene ExpressionHumansMaleMiddle AgedPhenotypeSeverity of Illness IndexSkinYoung Adultresearch article30685456open access10.1016/j.jaci.2019.01.0151097-6825http://www.jacionline.org/article/S0091674919301071/pdf