Jaimes-Bernal, ClaudiaRallon, NormaBenito, Jose MOmar, MohamedGomez-Vidal, Maria AmparoMarquez, Francisco JoseSanchez-Arcas, BeatrizTrujillo, MonteRoyo, Jose LuisSaulle, IrmaBiasin, MaraRivero-Juarez, AntonioCaruz, Antonio2023-01-252023-01-252018-10-04http://hdl.handle.net/10668/13033An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α-dependent cure of hepatitis C virus infection. The role of this polymorphism in the susceptibility to human immunodeficiency virus type 1 (HIV-1) infection is controversial. This study aimed to assess the association of this knockout IFNL4 variant and sexually transmitted HIV-1 infection. A total of 228 HIV-1-positive individuals and 136 HIV-exposed seronegative individuals were investigated for their association with IFNL4 rs368234815 genotypes. The IFNL4 ΔG functional allele is associated with increased susceptibility to HIV-1 infection through the sexual route (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.2-3.6; P = .004). A meta-analysis including a population of injection drug users suggests a codominant mode of inheritance of this risk factor (OR, 2.0; 95% CI, 1.3-3.2; P = .001).enHIV-1IFNAIFNL4USP18High exposed seronegativesDisease transmission, infectiousFemaleGenetic predisposition to diseaseGenotypeHIV infectionsHumansInterleukinsMaleSequence deletionResearch article30289470open accessEliminación de secuenciaGenotipoInfecciones por VIHInterleucinasPredisposición genética a la enfermedadTransmisión de enfermedad infecciosa10.1093/infdis/jiy5841537-6613https://academic.oup.com/jid/article-pdf/219/5/772/27785788/jiy584.pdf