Piñana, Jose LuisXhaard, AlienorTridello, GloriaPassweg, JakobKozijn, AnnePolverelli, NicolaHeras, InmaculadaPerez, AriadnaSanz, JaimeBerghuis, DagmarVazquez, LourdesSuarez-Lledo, MariaItala-Remes, MaijaOzcelik, TulayIturrate Basaran, IsabelKarakukcu, MusaAl-Zahrani, MohsenChoi, GodaCuesta-Casas, Marian AngelesBatlle-Massana, MontserratViviana, AmatoBlijlevens, NicoleGanser, ArnoldKuskonmaz, BarisLabussiere-Wallet, HeleneShaw, Peter JYegin, Zeynep ArzuGonzalez-Vicent, MartaRocha, VandersonFerster, AlinaKnelange, NinaNavarro, DavidMikulska, Malgorzatade-la-Camara, RafaelStyczynski, Jan2023-02-092023-02-092020-08-29Piñana JL, Xhaard A, Tridello G, Passweg J, Kozijn A, Polverelli N, et al. Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. J Infect Dis. 2021 May 20;223(9):1564-1575http://hdl.handle.net/10668/16174Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.enSeasonal human coronavirusHCoV-229EHCoV-HKU1HCoV-NL63HCoV-OC43Allogeneic hematopoietic stem cell transplantationCommunity-acquired respiratory virusImmunocompromisedImmunodeficiency score indexMultiplex PCR assayUpper and lower respiratory tract diseaseAdolescentAdultAgedBetacoronavirusChildChild, PreschoolCoronavirus 229E, HumanCoronavirus InfectionsCoronavirus NL63, HumanCoronavirus OC43, HumanFemaleHematopoietic Stem Cell TransplantationHospitalizationHumansInfantMaleMiddle AgedRespiratory Tract InfectionsRetrospective StudiesRisk FactorsSeasonsresearch article32860509Restricted AccessEnfermedades respiratoriasMortalidadRecuento de linfocitosTrasplante de médula óseaTrasplante de células madre10.1093/infdis/jiaa5531537-6613PMC7499673https://academic.oup.com/jid/article-pdf/223/9/1564/40327558/jiaa553.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499673/pdf