Grenville, Zoe SNoor, UrwahHis, MathildeViallon, VivianRinaldi, SabinaAglago, Elom KAmiano, PilarBrunkwall, LouiseChirlaque, María DoloresDrake, IsabelEichelmann, FabianFreisling, HeinzGrioni, SaraHeath, Alicia KKaaks, RudolfKatzke, VerenaMayén-Chacon, Ana-LuciaMilani, LorenzoMoreno-Iribas, ConchiPala, ValeriaOlsen, AnjaSanchez-Perez, Maria-JoseSchulze, Matthias BTjønneland, AnneTsilidis, Konstantinos KWeiderpass, ElisabeteWinkvist, AnnaZamora-Ros, RaulKey, Timothy JSmith-Byrne, KarlTravis, Ruth CSchmidt, Julie A2023-05-032023-05-032022-08-10Grenville ZS, Noor U, His M, Viallon V, Rinaldi S, Aglago EK, Amiano P, et al.Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer. Nutrients. 2022 Aug 12;14(16):3306.http://hdl.handle.net/10668/21494Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/cross-sectionaldietmetabolitesprostate cancerAnimalsBody Mass IndexCross-Sectional StudiesDietFishesGlutamatesHumansMaleProspective StudiesProstatic NeoplasmsRisk Factorsresearch article36014812open accessGlutamatosNeoplasias de la próstataDietaMasculinoÍndice de masa corporal10.3390/nu141633062072-6643PMC9415102https://www.mdpi.com/2072-6643/14/16/3306/pdf?version=1660298028https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415102/pdf