Vezza, TeresaGarrido-Mesa, JoseDiez-Echave, PatriciaHidalgo-Garcia, LauraRuiz-Malagon, Antonio JGarcia, FedericoSanchez, ManuelToral, MartaRomero, MiguelDuarte, JuanGuillamon, EnriqueBaños Arjona, AlbertoMoron, RocioGalvez, JulioRodriguez-Nogales, AlbaRodriguez-Cabezas, María Elena2023-02-092023-02-092021-07-25Vezza T, Garrido-Mesa J, Diez-Echave P, Hidalgo-García L, Ruiz-Malagón AJ, García F, Sánchez M, et al. Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties. Nutrients. 2021 Jul 28;13(8):2595.http://hdl.handle.net/10668/18452Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesity-associated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ẞ, Il-6, Tnf-α, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-α, Ppar-γ, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/cytokinesdysbiosisglucose metabolismlipid metabolismmicrobiotaobesityorganosulfur compoundAlliumAnimalsAnti-Inflammatory AgentsCytokinesDiet, High-FatDisease Models, AnimalGastrointestinal MicrobiomeGene ExpressionInflammationLiverMaleMiceMice, Inbred C57BLObesityPrebioticsPropaneSulfinic AcidsWeight Gainresearch article34444755open accessCitocinasMicrobioma gastrointestinalPrebióticosRatones Endogámicos C57BLExpresión Génica10.3390/nu130825952072-6643PMC8400710https://www.mdpi.com/2072-6643/13/8/2595/pdf?version=1628146242https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400710/pdf