Chajès, VéroniqueBiessy, CarineFerrari, PietroRomieu, IsabelleFreisling, HeinzHuybrechts, IngeScalbert, AugustinBueno de Mesquita, BasRomaguera, DoraGunter, Marc JVineis, PaoloHansen, Camilla PlambeckJakobsen, Marianne UhreClavel-Chapelon, FrançoiseFagherazzi, GuyBoutron-Ruault, Marie-ChristineKatzke, VeranaNeamat-Allah, JasmineBoeing, HeinerBachlechner, UrsulaTrichopoulou, AntoniaNaska, AndronikiOrfanos, PhilipposPala, ValeriaMasala, GiovannaMattiello, AmaliaSkeie, GuriWeiderpass, ElisabeteAgudo, AntonioHuerta, Jose MariaArdanaz, EvaSanchez-Perez, Maria-JoseDorronsoro, MirenQuirós, Jose RamonJohansson, IngegerdWinkvist, AnnaSonested, EmilyKey, TimKhaw, Kay-TeeWareham, Nicolas JPeeters, Petra H MSlimani, Nadia2015-08-132015-08-132015-02-12Chajès V, Biessy C, Ferrari P, Romieu I, Freisling H, Huybrechts I, et al. Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study. PLoS ONE 2015; 10(2):e0118206http://hdl.handle.net/10668/1969Journal Article;BACKGROUND Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow-up, age, energy, alcohol, smoking status, physical activity, and region. RESULTS In women, doubling elaidic acid was associated with a decreased risk of weight loss (odds ratio (OR) = 0.69, 95% confidence interval (CI) = 0.55-0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5-year follow-up (OR = 1.23, 95% CI = 0.97-1.56, p = 0.082) (p-trend<.0001). In men, a trend was observed for doubling elaidic acid level and risk of weight loss (OR = 0.82, 95% CI = 0.66-1.01, p = 0.062) while no significant association was found with risk of weight gain during the 5-year follow-up (OR = 1.08, 95% CI = 0.88-1.33, p = 0.454). No association was found for saturated and cis-monounsaturated fatty acids. CONCLUSIONS These data suggest that a high intake of industrial trans fatty acids may decrease the risk of weight loss, particularly in women. Prevention of obesity should consider limiting the consumption of highly processed foods, the main source of industrially-produced trans fatty acids.enMarcadores biológicosPeso corporalDietaEstudios epidemiológicosÁcidos grasosNeoplasiasEstado NutricionalÁcidos OléicosMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological MarkersMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body WeightMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::DietMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic StudiesMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty AcidsMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional StatusMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Fatty Acids, Monounsaturated::Oleic Acidsresearch article25675445open access10.1371/journal.pone.01182061932-6203PMC4326417