Rodriguez, Carlos EPalacios, JavierFajardo, IgnacioUrdiales, Jose LuisLe Guevel, XavierLozano, JoseSanchez-Jimenez, Francisca2023-01-252023-01-252015-11-30Rodríguez CE, Palacios J, Fajardo I, Urdiales JL, Le Guével X, Lozano J, et al. Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides. J Am Soc Mass Spectrom. 2016 Feb;27(2):366-9.http://hdl.handle.net/10668/9645This is the first study where graphene is used as a MALDI adjuvant in combination with the traditional matrix α-cyano-4-hydroxycinnamic acid (CHCA) to improve the signal intensity of peptide samples. Use of this amended matrix not only leads to increased signals but also to a higher number of peaks detected in complex samples. Additionally, the use of graphene has a stabilizing effect that can also be exploited to improve the detection of easily cleavable molecules.enGrapheneMALDI-TOF/TOFPhosphorylated peptidesGraphitePeptidesPhosphoproteinsPhosphorylationSignal Processing, Computer-AssistedSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationresearch article26620529open accessDiagnósticoGrafitoPéptidosÁcidos cumáricos10.1007/s13361-015-1299-31879-1123https://hal.archives-ouvertes.fr/hal-02338004/file/Conventional%20Matrices%20Loaded%20Onto%20a%20Graphene%20Layer%20Enhances%20MALDI-TOF_TOF%20Signal-%20Its%20Application%20to%20Improve%20Detection%20of%20Phosphorylated%20Peptides.pdf