Sanchez-Larsen, AlvaroConde-Blanco, EstefaniaViloria-Alebesque, AlejandroSanchez-Vizcaino Buendia, CristinaEspinosa Oltra, TatianaAlvarez-Noval, AmandaAledo-Serrano, AngelMartin-Garcia, RaquelRamos-Araque, Maria E.Campos, DulceValle-Penacoba, GonzaloSierra-Gomez, AliciaDe Ceballos-Cerrajeria, PabloAgundez-Sarasola, MartaKhawaja, MariamHampel, Kevin G.Serra-Martinez, MariaArbos-Barber, ClaraGomez-Ibanez, AsierVillino-Boquete, RafaelCabezudo-Garcia, PabloRodriguez-Lavado, IgnacioPrincipe, AlessandroSopelana-Garay, David2025-01-072025-01-072021-10-291525-5050https://hdl.handle.net/10668/24532Background: To assess the prevalence, severity, and mortality of COVID-19 in people with epilepsy (PWE) and evaluate seizure control in PWE during and after COVID-19. Methods: Retrospective, observational, multicenter study conducted in 14 hospitals. Medical records of randomly selected PWE followed at neurology outpatient clinics were reviewed. Proportion of PWE with a positive test for SARS-CoV-2 during 2020 was calculated. Risk factors associated with COVID-19 and its morbimortality were evaluated. Results: 2751 PWE were included, mean age 48.8 years (18-99), 72.4% had focal epilepsy, and 35% were drug-refractory. COVID-19 prevalence in PWE was 5.53%, while in the Spanish population was 4.26%. Proportion of admissions to hospital, ICU, and deaths in PWE were 17.1%, 2%, and 4.61% of COVID-19 cases, while in Spanish population were 10.81%, 0.95%, and 2.57%, respectively. A severe form of COVID-19 occurred in 11.8%; dyslipidemia, institutionalization at long-term care facilities, intellectual disability, and older age were associated risk factors. Older age, hypertension, dyslipidemia, cardiac disease, and institutionalization were associated with mortality from COVID-19. Seizure control was stable in 90.1% of PWE during acute COVID-19, while 8.6% reported an increase in seizure frequency. During post-COVID-19 follow-up, 4.6% reported seizure control worsening.enCOVID-19Coronavirus SARS-CoV-2PrevalenceEpilepsySeizuresIlae commissionPosition paperClassificationresearch article34731719open access10.1016/j.yebeh.2021.1083791525-5069https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759834716169200003